HPLC Determination of Arbidol (Umifenovir) on Newcrom AH Column

HPLC Method for Arbidol (Umifenovir) on Newcrom AH by SIELC Technologies

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Arbidol (Umifenovir).

Umifenovir is an antiviral medication with the chemical formula C22H25BrN2O3S. It is used to treat influenza in Russia and China for decades, but it is not approved for use in the United States by the Food and Drug Administration (FDA).  It is considered a direct-acting antiviral as well as a host-targeting agent due to how it effects multiple stages of a viral lifecycle. Due to it’s wide-spread capabilities in covering both enveloped and non-enveloped RNA and DNA viruses, it is currently being investigated as treatment and prevention of COVID-19 caused by SARS-CoV-2 infections.

Arbidol (Umifenovir) can be retained and analyzed using the Newcrom AH stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN). Detection is performed using UV.

Condition
Column Newcrom AH, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 60/40%
Buffer AmFm pH 3.0- 50 mM
Flow Rate 1.0 ml/min
Detection UV 255 nm,  MS-compatible mobile phase

Description
Class of Compounds Hydrophobic, Drug
Analyzing Compounds Arbidol (Umifenovir)

Application Column

Newcrom AH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Arbidol (Umifenovir)
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.