Docusate sodium

CAS Number	577-11-7
Molecular Formula	C20H37NaO7S
Molecular Weight	444.560
InChI Key	APSBXTVYXVQYAB-UHFFFAOYSA-M
LogP	4.32
Synonyms	Docusate sodium Aerosol OT Colace DEH Na SS DEH-Na-SS diethylhexyl sodium sulfosuccinate Dioctyl Sulfosuccinate Dioctyl Sulfosuccinate, Sodium Dioctyl Sulfosuccinates Dioctyl Sulfosuccinic Acid Dioctyl Sulfosuccinic Acid, Ammonium Salt Dioctyl Sulfosuccinic Acid, Barium Salt Dioctyl Sulfosuccinic Acid, Calcium Salt Dioctyl Sulfosuccinic Acid, Magnesium Salt Dioctyl Sulfosuccinic Acid, Potassium Salt Dioctyl Sulfosuccinic Acid, Sodium Salt Dioctylsulfosuccinate Dioctylsulphosuccinate, Sodium Docusate Docusate Calcium Docusate Potassium Docusate Sodium DOSS Sodium Bis(2-ethylhexyl)sulfosuccinate Sodium Dioctyl Sulfosuccinate Sodium Dioctylsulphosuccinate Sodium Sulfosuccinate, Diethylhexyl Sulfosuccinate, Diethylhexyl Sodium Sulfosuccinate, Dioctyl Sulfosuccinates, Dioctyl Sulfosuccinic Acid bis(2-Ethylhexyl) Ester Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1) 577-11-7 Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Bis(2-ethylhexyl) sodium sulfosuccinate Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt 1,4-Bis(2-ethylhexyl) sodium sulfosuccinate 1,4-BIS(2-ETHYLHEXYL)SULFOSUCCINIC ACID SODIUM SALT Acrosol OT 100 Adekacol EC 4500 Adekacol EC 8600 Aerosol A 501 Aerosol AOT Aerosol GPG Aerosol OT Aerosol OT 100 Aerosol OT 70 Aerosol OT 70PG Aerosol OT 75 Aerosol OT 75E Aerosol OT 75PG Aerosol OT 94 Aerosol OT-A Aerosol OT-B Aerosol OT-S Airrol CT 1 Airrol CT 1L Airrol OP Alcopol O Alkasurf SS-O 75 Alphasol OT Astrowet 608 Astrowet O 70PG Astrowet O 75 Bis(2-ethylhexyl) sodiosulfosuccinate Bis(2-ethylhexyl) S-sodium sulfosuccinate Bis(2-ethylhexyl) sulfosuccinate sodium salt Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1) Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl)ester, sodium salt BUTANEDIOIC ACID, SULFO-, BIS-2-ETHYLHEXYL ESTER, SODIUM SALT BUTANEDIOIC ACID, SULFO-,1,4-BIS(2-ETHYLHEXYL) ESTER, SODIUM SALT Butanedioic acid, sulfo-1,4-bis(2-ethylhexyl) este-r, sodium salt Carabon DA 72 Celanol DOS 65 Celanol DOS 75 Chemax DOSS 70PG Comfolax Complemix Constonate Coprola Correctol Stool Softener Laxative Defilin Di(2-ethylhexyl) sulfosuccinate sodium salt Di(2-ethylhexyl)sulfosuccinic acid, sodium salt Di-2-ethylhexyl sodium sulfosuccinate DI-2-ETHYLHEXYL SULFOSUCCINIC ACID SODIUM SALT Dialose Dioctlyn Dioctyl Dioctyl sulfosuccinate sodium Dioctyl sulfosuccinate sodium salt Dioctylal Dioctyl-Medo Forte DioctylSodium Sulfosuccinate Diomedicone Diosuccin Diotilan Disonate Disposaject Docusate sodique Docusatnatrium docusato sodico Doxinate Drewfax 007 Dulcivac Dulsivac Empimin OP 70 Empimin OT 75 Freetex OT Gemtex SC Gemtex SC 40 Genopur SB 1970J Geropon DOS Geropon SS-O 75 Geropon WT 27 Humifen WT 27G Isoprotanc Karawet DOSS Koremul 290 Lankropol 4500 Lankropol KO 2 Laxinate Lumiten I-RA Lutensit A-BO Lutensit A-BOS Mackanate DOS 75 Manoxol Manoxol OP Manoxol OT Marlinat DF 8 Mervamine Miconate DOS Modane Soft Molatoc Molofac Monawet M 085P Monawet MO 65-150 Monawet MO 70 Monawet MO 70E Monawet MO 70R Monowet MO 70R Monowet MO-E 75 Neocol P Neocol YSK Neopelex OTP Newcol 290M Newcol 291EG Newcol 291M Newcol 291PG Newkalgen EP 60P Newkalgen EP 70G Nikkol OTP 100 Nikkol OTP 100S Nikkol OTP 70 Nikkol OTP 75 Nissan Rapisol Nissan Rapisol A 30 Nissan Rapisol A 80 Nissan Rapisol A 90 Nissan Rapisol B 07 Nissan Rapisol B 30 Nissan Rapisol B 80 Nissan Rapisol B 90 Octowet Pelex OT Pelex OT-P Persol KMN 3 Pionin A 51B Rapisol Rapisol A 30 Rapisol A 80 Rapisol A 90 Rapisol B 30 Rapisol B 80 Rapisol B 90 Regutol Rewopol SBDO 70 Rikakoru M 75 Sanmorin OT Sanmorin OT 70 Sanmorin OT 70N Sanseparer 100 Secosol DOS 70 SN-Wet OT 70 Sobital Sodium 1,2-bis(2-ethylhexyloxycarbonyl)-1-ethanesulfonate Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate Sodium bis(2-ethylhexyl) sulfosuccinate Sodium bis(ethylhexyl) sulfosuccinate Sodium di(2-ethylhexyl) sulfosuccinate Sodium di(ethylhexyl) sulfosuccinate sodium dioctyl sulfosuccinate aerosol ot 75 sponto ha Sodium docusate Soliwax Solovet Solusol Succinate STD Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt SUCCINIC ACID, SULFO-, 1,4-BIS(2-ETHYLHEXYL) ESTERSODIUM SALT Sulfimel DOS SULFOBERNSTEINSAEURE-1,4-BIS-(2-AETHYLHEXYL)-ESTER-NA-SALZ Sulfobutanedioic acid 1,4-bis(2-ethylhexyl)ester sodium salt Sulfobutanedioic acid, 1,4-bis(2-ethylhexyl) ester, sodium salt SULFOSUCCINATE, 2-ETHYLHEXYL, SODIUM Sulfosuccinic acid bis(2-ethylhexyl)ester sodium salt Sulfosuccinic acid di-2-ethylhexyl ester sodium salt Sunnol LDF 110 Surfonic DOS 75PG Talosurf Tex-Wet 1001 Triton GR 5 Triton GR 5M Triton GR 7 Triton GR 7M Triton GR 7ME Vatsol OT Warcowet 060 Wetaid SR Bis(ethylhexyl) ester of sodium sulfosuccinic acid Bis(2-ethylhexyl)sodium sulfosuccinate Clestol Dioctyl ester of sodium sulfosuccinate Dioctyl ester of sodium sulfosuccinic acid EINECS 209-406-4 2-Ethylhexyl sulfosuccinate sodium Laxinate 100 Manoxal OT Monawet MD 70E Monawet MO-70 Monawet MO-84 R2W Monawet MO-70 RP Monoxol OT Natrii dioctylsulfosuccinas Nekal WT-27 Requtol Sodium dioctyl sulphosuccinate Sodium 2-ethylhexylsulfosuccinate Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate Solusol-100% Solusol-75% Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt Triton GR-5 Coloxyl Bis-2-ethylhexylester sulfojantaranu sodneho Docusatum natricum Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego Dioctyl sodium sulphosuccinat UNII-F05Q2T2JA0 Bloat treatment Docuprene Docolace Doc Q Lace 105956-73-8 106396-28-5 110162-65-7 113255-61-1 12640-70-9 130390-93-1 133136-80-8 135843-72-0 138893-51-3 141092-35-5 154608-80-7 201816-76-4 202352-75-8 209122-63-4 209453-97-4 29732-38-5 336190-18-2 51910-13-5 52624-44-9 53023-94-2 56833-49-9 59030-04-5 60202-21-3 66812-62-2 67924-68-9 75418-10-9 76689-26-4 78207-03-1 835616-33-6 590366-27-1 1420177-77-0 1644530-78-8

Applications:

HPLC Determination of Docusate Sodium in Softgels on Newcrom BH Column

August 5, 2021

View Application

Separation type: Liquid Chromatography Mixed-mode

View on hplc.cloud

High Performance Liquid Chromatography (HPLC) Method for Analysis of Docusate.

Docusate is used as a laxative and stool softener. Docusate retains water in the stool, thereby acting as a stool softener to facilitate stool passage. Docusate can be retained on the Newcrom BH mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. The analysis method can be UV detected at 200 nm.

Condition
Column	Newcrom BH, 3.2×100 mm, 3 µm, 100A
Mobile Phase	MeCN/H2O -75/25%
Buffer	H2SO4 – 0.5%
Flow Rate	0.5 ml/min
Detection	UV, 200 nm

Description
Class of Compounds	Drug
Analyzing Compounds	Docusate Sodium

Application Column

Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options

Dioctyl sulfosuccinic acid
Docusate sodium

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Docusate sodium on Newcrom R1 HPLC column

May 16, 2018

View Application

Separation of Docusate sodium on Newcrom R1 HPLC column

Docusate sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

Select options

Docusate sodium

Change simulation parameters

The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.

HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid

July 10, 2012

View Application

Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent. It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.

Application Columns: Primesep B4

Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid

Detection technique: LC/MS, ELSD/CAD

Condition
Column	Primesep B4, 3.2×50 mm, 5 µm, 100A
Mobile Phase	Gradient MeCN – 10 -50%, 10 min
Buffer	Gradient AmFm pH 3.0- 60-180 mM, 10 min
Flow Rate	1.0 ml/min
Detection	ELSD

Description
Class of Compounds	Acid, Hydrophilic, Ionizable
Analyzing Compounds	Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid

Application Column

Primesep B2

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options