2-Hydroxyethyl salicylate

2-Hydroxyethyl salicylate structural formula

 

CAS Number87-28-5
Molecular FormulaC9H10O4
Molecular Weight182.176
InChI KeyLVYLCBNXHHHPSB-UHFFFAOYSA-N
LogP1.39
Synonyms
  • 2-Hydroxyethyl salicylate
  • 2-Hydroxyethyl 2-hydroxybenzoate
  • Benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
  • 87-28-5
  • EINECS 201-737-2
  • Espirosal
  • Ethylene glycol, monosalicylate
  • 1,2-Ethylene glycol monosalicylate
  • Ethylene glycol, salicylate
  • Monoglycol salicylate
  • NSC 72097
  • Rheumacyl
  • Sarocol
  • Spirosal
  • Aethylenglykolsalicylat
  • Ethylenglycol-monosalicylsaeureester
  • Glykolsalicylat
  • Traumasenex
  • Phlogont
  • Kytta-gel
  • UNII-3I1VBB7AXH
  • 2-hydroxybenzoic acid 2-hydroxyethyl ester
  • 2-hydroxyethyl 2-oxidanylbenzoate
  • Ethylene glycol salicylate
  • ethylene glycol monosalicylate

Applications:

HPLC Separation of Mixture of 2-Hydroxyethyl Salicylate and Salicylic Acid on Primesep B Column

August 14, 2019

HPLC Separation of Mixture of 2-Hydroxyethyl Salicylate and Salicylic Acid_1182

2-Hydroxyethyl salicylate is a drug used as analgesic agents for the treatment of mild to moderate pain.

 

Condition
Column Primesep B, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 25/75%
Buffer H2SO4 – 0.5 %
Flow Rate 1.0 ml/min
Detection UV, 238 nm

 

Description
Class of Compounds
 Acid, Hydrophilic, Ionizable, Carboxylic acid, Drug, Carbocyclic, Benzoate, Hydroxy Acid, Hydroxybenzoate, Phenol
Analyzing Compounds 2-Hydroxyethyl Salicylate, Salicylic Acid

 

Application Column

Primesep B

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
2-Hydroxyethyl salicylate
Salicylic acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of 2-Hydroxyethyl salicylate on Newcrom R1 HPLC column

February 16, 2018
Separation of 2-Hydroxyethyl salicylate on Newcrom C18 HPLC column

2-Hydroxyethyl salicylate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
2-Hydroxyethyl salicylate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.