Quinolinic acid

Quinolinic acid

CAS Number89-00-9
Molecular Formula C7H5NO4
Molecular Weight167.12
InChI KeyGJAWHXHKYYXBSV-UHFFFAOYSA-N
LogP0.2
Synonyms
  • quinolinic acid
  • Pyridine-2,3-dicarboxylic acid
  • 89-00-9
  • 2,3-pyridinedicarboxylic acid
  • quinolinate
  • 339155-13-4
  • 2,3-pyridine dicarboxylic acid
  • pyridinedicarboxylic acid
  • Pyridine-2,3-dicarboxylate
  • AI3-63017
  • C7H5NO4
  • pyridine-2,3-carboxylate
  • MFCD00006295
  • F6F0HK1URN
  • CHEMBL286204
  • 28605-84-7
  • DTXSID8041327
  • CHEBI:16675
  • NSC-13127
  • 2,3-pyridinedicarboxylate
  • 2,3-Pyridinedicarboxylicacid, labeled with tritium (9CI)
  • 2,3-PyridinedicarboxylicAcid
  • SMR000112287
  • SR-01000075472
  • EINECS 201-874-8
  • UNII-F6F0HK1URN
  • NSC 13127
  • quinolinic-acid
  • HSDB 7511
  • Spectrum_001525
  • Tocris-0225
  • pyridine carboxylate, 6c
  • Spectrum2_000929
  • Spectrum3_001502
  • Spectrum4_000336
  • Spectrum5_001170
  • Lopac-P63204
  • bmse000219
  • EC 201-874-8
  • pyridine, 2,3-dicarboxy-
  • Pyridin-2,3-dicarbonsaeure
  • Lopac0_000989
  • Oprea1_139764
  • SCHEMBL69230
  • BSPBio_003143
  • KBioGR_000711
  • KBioSS_002005
  • QUINOLINIC ACID [MI]
  • MLS001332417
  • MLS001332418
  • MLS002153210
  • DivK1c_000773
  • Pyridine-2,3-dicarboxylicacid
  • SPECTRUM1502102
  • SPBio_000838
  • pyridine-5,6-dicarboxylic acid
  • DTXCID6021327
  • BDBM26115
  • HMS502G15
  • KBio1_000773
  • KBio2_002005
  • KBio2_004573
  • KBio2_007141
  • KBio3_002643
  • NINDS_000773
  • HMS1921J12
  • HMS2267B04
  • HMS3263E19
  • HMS3266C15
  • HMS3411C05
  • HMS3675C05
  • HMS3885A17
  • NSC13127
  • NSC18836
  • Tox21_302051
  • Tox21_500989
  • BBL007601
  • CCG-39677
  • HB0544
  • NSC-18836
  • NSC403247
  • PDSP1_000133
  • PDSP2_000132
  • s3624
  • STK365157
  • 2,3-Pyridinedicarboxylic acid, 99%
  • AKOS000119760
  • AM81291
  • CS-W020665
  • DB01796
  • FG-0461
  • LP00989
  • NSC-403247
  • PB47350
  • SDCCGMLS-0411909.P028
  • SDCCGSBI-0050962.P003
  • CAS-89-00-9
  • IDI1_000773
  • MLS-0411909
  • NCGC00015865-01
  • NCGC00015865-02
  • NCGC00015865-03
  • NCGC00015865-04
  • NCGC00015865-05
  • NCGC00015865-06
  • NCGC00015865-07
  • NCGC00015865-08
  • NCGC00015865-12
  • NCGC00024506-01
  • NCGC00024506-02
  • NCGC00024506-03
  • NCGC00024506-04
  • NCGC00024506-05
  • NCGC00024506-06
  • NCGC00255468-01
  • NCGC00261674-01
  • AC-11734
  • SY003044
  • 2,3-Pyridinedicarboxylic acid (8CI,9CI)
  • MLS-0411909.P016
  • DB-016184
  • HY-100807
  • EU-0100989
  • FT-0609764
  • FT-0674187
  • FT-0689818
  • NS00006026
  • P0550
  • EN300-18090
  • C03722
  • D70926
  • P63204
  • AC-907/25014157
  • Q411945
  • J-019373
  • Q-201654
  • SR-01000075472-1
  • SR-01000075472-3
  • Z57160166
  • F2191-0231
  • 2,3-Pyridinedicarboxylic acid, Vetec(TM) reagent grade, 98%
  • InChI=1/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12

Applications:

HPLC Method for Analysis of Quinolinic acid on Newcrom BH Column

October 4, 2023

HPLC Method for Analysis of Quinolinic acid on Newcrom BH Column by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Analysis of Quinolinic acid on Newcrom BH Column_1684

Quinolinic acid (also known as quinolinate or 2,3-pyridinedicarboxylic acid) is a dicarboxylic acid with a pyridine backbone. It plays a role in various biological processes and is associated with some pathological conditions.

Biochemical Role:

  • Quinolinic acid is a metabolite in the kynurenine pathway, which is responsible for the catabolism of tryptophan, an essential amino acid.
  • It serves as a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in cellular redox reactions.

Neurological Significance:

  • Quinolinic acid can act as an excitotoxin in the brain, meaning it can overactivate nerve cells potentially leading to damage or death of the cells.
  • High levels of quinolinic acid have been associated with various neurodegenerative disorders, such as Alzheimer’s disease, Huntington’s disease, and others, due to its ability to overstimulate neurons through the N-methyl-D-aspartate (NMDA) receptor.

Chemical Properties:

  • Quinolinic acid has a somewhat polar character due to the carboxylic acid groups and the nitrogen in the pyridine ring.
  • It is a weak acid and can lose protons from the carboxylic acid groups, forming salts in neutral and basic conditions.

Environmental Presence:

  • Quinolinic acid, like other biologically active molecules, may be found in various environmental contexts, like in soil and water, through natural processes or as a result of anthropogenic activities, such as the use of pesticides that may contain pyridine derivatives.

Quinolinic acid can be retained and analyzed on a mixed-mode Newcrom BH column with a mobile phase consisting of water, Acetonitrile (MeCN), and posphoric acid. This analytical method can detect compounds with high resolution and peak symmetry using UV detection at 200 nm

High Performance Liquid Chromatography (HPLC) Method for Analyses of Quinolinic acid

Condition

ColumnNewcrom BH, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN – 20%
Buffer H3PO4 – 0.2%
Flow Rate1.0 ml/min
Peak Retention Time5.38 min
Detection200 nm

Description

Class of CompoundsAcid
Analyzing CompoundsQuinolinic acid

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Quinolinic acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.