Methyl 2-acetylacetoacetate

Methyl 2-acetylacetoacetate structural formula

CAS Number4619-66-3
Molecular FormulaC7H10O4
Molecular Weight158.153
InChI KeyUHCPCQYUMVLUKU-UHFFFAOYSA-N
LogP0.518
Synonyms
  • Methyl 2-acetylacetoacetate
  • Methyl 2-acetyl-3-oxobutanoate
  • Butanoic acid, 2-acetyl-3-oxo-, methyl ester
  • 4619-66-3
  • 4-03-00-01780
  • BRN 1706278
  • EINECS 225-031-9
  • Methyl 2-acetyl-3-oxobutanoate
  • Methyl diacetoacetate
  • Methyl diacetylacetate
  • Methylester kyseliny diacetoctove
  • UNII-ULU5MKD9FL

Applications:

Separation of Methyl 2-acetylacetoacetate on Newcrom R1 HPLC column

May 16, 2018
Separation of Methyl 2-acetylacetoacetate on Newcrom R1 HPLC column

Methyl 2-acetylacetoacetate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Methyl 2-acetylacetoacetate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.