HPLC Method for Separation of Levamisole, Mebendazole on Primesep 100 by SIELC Technologies

Levamisole, Mebendazole are both anthelmintic drugs, meaning they are used to treat parasitic worm infections. Each works in a different way and is used to treat different types of infections:

Levamisole is a medication with the chemical formula C₁₁H₁₃ClN₂S. It is used primarily to treat worm infections. It works by paralyzing the worms which are then expelled from the body by the immune system. In the past, it was also used as an immune stimulant in some types of cancer and rheumatoid arthritis. However, its use for these conditions has decreased due to the risk of serious side effects.

Mebendazole is also an anthelmintic medication with the chemical formula C₁₆H₁₃N₃O₃. It is used to treat a variety of parasitic worm infections, including roundworm, hookworm, whipworm, and pinworm. Mebendazole works by preventing the worms from absorbing sugars which they need to survive. This kills the worm within a few days. Although this medicine can be used for children, it should not be given to children under 2 years old.

Both drugs are typically taken orally, often as a single dose, but the exact dosage and length of treatment depend on the type of infection being treated. Like all medications, Levamisole and Mebendazole have potential side effects, and they should be used under the supervision of a healthcare provider. It’s also important to remember that hygiene practices are crucial in preventing reinfection with worms, especially in areas where such infections are common.

Levamisole, Mebendazole can be retained, separated, and analyzed using a reverse-phase Primesep 100 column. The mobile phase for this method consists of water, acetonitrile (MeCN), and Sulfuric acid, which serves as a buffer. This analytical method can be

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