HPLC Method For Analysis Of 2,3-Dichlorobenzoic Anhydride on Primesep S2 Column

Separation type: Liquid Chromatography HILIC

 

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of 2,3-Dichlorobenzoic anhydride

2,3-Dichlorobenzoic Anhydride is an impurity formed during the production of Lamotrigine, anticonvulsant used to treat epileptic seizures and Bipolar Disorder. Removing 2,3-Dichlorobenzoic Anhydride is paramount for maximizing Lamotrigine purity. 2,3-Dichlorobenzoic Anhydride can be retained and analyzed on a mixed-mode Primesep S2 column with a mobile phase consisting of just Acetonitrile (MeCN) without water or a buffer. This analytical method can be UV detected at 210 nm with high resolution and peak symmetry.

Condition
Column Primesep S2, 4.6×250 mm, 5 µm, 100A
Mobile Phase MeCN- 100%
Buffer No
Flow Rate 1.0 ml/min
Detection UV 210 nm

Description
Class of Compounds Anhydride
Analyzing Compounds 2,3-Dichlorobenzoic anhydride

 

Application Column

Primesep S2

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
2,3-Dichlorobenzoic anhydride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.