Demethoxycurcumin

Demethoxycurcumin 22608-11-3 24939-17-1 curcumin II monodemethoxycurcumin desmethoxycurcumin BHCFM 4-Hydroxycinnamoyl(feroyl)methane Demethoxy Curcumin 33171-16-3 (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione Feruloyl-P-hydroxycinnnamoylmethane curcuminII (E/Z)-Demethoxycurcumin 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)- p-Hydroxycinnamoylferuloylmethane UNII-W2F8059T80 CHEBI:65737 4-hydroxycinnamoyl(feruloyl)methane C20H18O5 NSC687841 (1E,6E)-1-(4-HYDROXY-3-METHOXY-PHENYL)-7-(4-HYDROXYPHENYL)HEPTA-1,6-DI ENE-3,5-DIONE W2F8059T80 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione p-Hydroxycinnamoyl-feruloylmethane demethoxy-curcumin (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-hepta-1,6-diene-3,5-dione 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)- (2E)-Demethoxy Curcumin MFCD03427310 Curcumin II;Desmethoxycurcumin;Monodemethoxycurcumin feruloyl-p-coumaroylmethane D03EDF (E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione SCHEMBL431246 CHEMBL105360 INS NO.100(II) SCHEMBL2553051 DEMETHOXYCURCUMIN [INCI] SCHEMBL13521973 SCHEMBL23884878 SCHEMBL23884879 cid_5324476 HY-N0006A INS-100(II) DTXSID00873751 DESMETHOXYCURCUMIN [USP-RS] Demethoxycurcumin, >=98% (HPLC) BDBM50163744 E-100(II) s9280 Demethoxycurcumin, analytical standard AKOS015903509 CCG-267896 NSC-687841 AC-34584 BS-48948 CS-0009120 A14545 A910179 6-Bromo-2-pyridin-4-yl-quinoline-4-carboxylicacid Q-100287 Q5264607 1-(4-Hydroxystyryl)-3-(3-methoxy-4-hydroxystyryl)propanedial (1E,6E)-1-(4-Hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,6-diene-3,5-dione 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)- (VAN) 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, 9CI 1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one (1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,4,6-trien-3-one (1E,6E)-1-(4-HYDROXY-3-METHOXY-PHENYL)-7-(4-HYDROXYPHENYL)HEPTA-1,6-DIENE-3,5-DIONE

CAS Number22608-11-3
Molecular Formula C20H18O5
Molecular Weight338.4
InChI KeyHJTVQHVGMGKONQ-LUZURFALSA-N
LogP3.3
Synonyms
  • Demethoxycurcumin
  • 22608-11-3
  • 24939-17-1
  • curcumin II
  • monodemethoxycurcumin
  • desmethoxycurcumin
  • BHCFM
  • 4-Hydroxycinnamoyl(feroyl)methane
  • Demethoxy Curcumin
  • 33171-16-3
  • (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
  • Feruloyl-P-hydroxycinnnamoylmethane
  • curcuminII
  • (E/Z)-Demethoxycurcumin
  • 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
  • 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-
  • p-Hydroxycinnamoylferuloylmethane
  • UNII-W2F8059T80
  • CHEBI:65737
  • 4-hydroxycinnamoyl(feruloyl)methane
  • C20H18O5
  • NSC687841
  • (1E,6E)-1-(4-HYDROXY-3-METHOXY-PHENYL)-7-(4-HYDROXYPHENYL)HEPTA-1,6-DI ENE-3,5-DIONE
  • W2F8059T80
  • 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • p-Hydroxycinnamoyl-feruloylmethane
  • demethoxy-curcumin
  • (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-hepta-1,6-diene-3,5-dione
  • 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-
  • (2E)-Demethoxy Curcumin
  • MFCD03427310
  • Curcumin II;Desmethoxycurcumin;Monodemethoxycurcumin
  • feruloyl-p-coumaroylmethane
  • D03EDF
  • (E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • SCHEMBL431246
  • CHEMBL105360
  • INS NO.100(II)
  • SCHEMBL2553051
  • DEMETHOXYCURCUMIN [INCI]
  • SCHEMBL13521973
  • SCHEMBL23884878
  • SCHEMBL23884879
  • cid_5324476
  • HY-N0006A
  • INS-100(II)
  • DTXSID00873751
  • DESMETHOXYCURCUMIN [USP-RS]
  • Demethoxycurcumin, >=98% (HPLC)
  • BDBM50163744
  • E-100(II)
  • s9280
  • Demethoxycurcumin, analytical standard
  • AKOS015903509
  • CCG-267896
  • NSC-687841
  • AC-34584
  • BS-48948
  • CS-0009120
  • A14545
  • A910179
  • 6-Bromo-2-pyridin-4-yl-quinoline-4-carboxylicacid
  • Q-100287
  • Q5264607
  • 1-(4-Hydroxystyryl)-3-(3-methoxy-4-hydroxystyryl)propanedial
  • (1E,6E)-1-(4-Hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,6-diene-3,5-dione
  • 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)- (VAN)
  • 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, 9CI
  • 1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione
  • 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one
  • (1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,4,6-trien-3-one
  • (1E,6E)-1-(4-HYDROXY-3-METHOXY-PHENYL)-7-(4-HYDROXYPHENYL)HEPTA-1,6-DIENE-3,5-DIONE

Applications:

UV-Vis Spectrum of Demethoxycurcumin

July 25, 2024
UV-Vis Spectrum of Demethoxycurcumin. Absorption Maxima: 194 nm, 264 nm, 425 nm.

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Demethoxycurcumin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Curcuminoids in Turmeric Capsules on Newcrom R1  Column

September 21, 2023

HPLC Method for Analysis of Curcumin, Bisdemethoxycurcumin, Demethoxycurcumin on Newcrom R1 Column by SIELC Technologies

Separation type: Liquid Chromatography Reversed-phase

HPLC Method for Analysis of Curcuminoids in Turmeric Capsules on Newcrom R1  Column
HPLC Method for Analysis of Curcumin, Bisdemethoxycurcumin, Demethoxycurcumin on Newcrom R1 Column by SIELC Technologies

Turmeric is a yellow spice derived from the rhizomes of the plant Curcuma longa. It has been used for centuries in culinary and medicinal traditions, especially in Indian and Southeast Asian cultures. One of the main bioactive components responsible for many of turmeric’s potential health benefits is curcumin.

The curcumin content in turmeric varies depending on the source and preparation, but typically, dried turmeric powder contains about 2-5% curcumin by weight. This relatively low percentage is one reason why many curcumin supplements are made using extracts to provide a concentrated dose.

Curcumin is not a single compound but is rather a mixture of related compounds known as curcuminoids.

Curcuminoids are a group of polyphenolic compounds found in turmeric (Curcuma longa). They are responsible for the yellow color of the turmeric spice and are also the main bioactive components believed to be responsible for many of the potential health benefits of turmeric.

The three primary curcuminoids in turmeric are:

Curcumin (diferuloylmethane): This is the primary and most studied component, accounting for 60-70% of the curcuminoids in turmeric.
Demethoxycurcumin: This compound constitutes about 20-27% of the curcuminoids.
Bisdemethoxycurcumin: This makes up around 10-15% of the curcuminoids.
These compounds have been studied for their potential anti-inflammatory, antioxidant, anticancer, and neuroprotective properties, among others. Due to their low bioavailability, many formulations, such as those combined with piperine (from black pepper), have been developed to enhance absorption in the body.

Curcuminoids can be retained, separated, and analyzed on a mixed-mode Newcrom R1 column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid. This analytical method can be detected with high resolution and peak symmetry at a wavelength of 425 nm using Vis detection

High Performance Liquid Chromatography (HPLC) Method for Analyses of Curcumin, Bisdemethoxycurcumin, Demethoxycurcumin on Newcrom R1 Column by SIELC Technologies

Condition

ColumnNewcrom R1, 0.5 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 50/50%,
BufferH2SO4 – 0.2%
Flow Rate1.0 ml/min
DetectionVis 425 nm

Description

Class of CompoundsPolyphenols
Analyzing CompoundsCurcumin, Bisdemethoxycurcumin, Demethoxycurcumin

Application Column

Newcrom R1

Column Diameter: 0.5 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Bisdemethoxycurcumin
Curcumin
Demethoxycurcumin
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.