Acetylsalicylic anhydride

Acetylsalicylic anhydride structural formula

CAS Number1466-82-6
Molecular FormulaC18H14O7
Molecular Weight342.304
InChI KeyOAWXYINGQXLWOE-UHFFFAOYSA-N
LogP1.95
Synonyms
  • Acetylsalicylic anhydride
  • 2-(Acetyloxy)benzoic anhydride
  • 1466-82-6
  • 2-(Acetyloxy)benzoic acid anhydride
  • Acetylsalicylic acid anhydride
  • Aspirin anhydride
  • BRN 2015320
  • Contraflu
  • EINECS 215-987-5
  • NSC 63848
  • NSC 80056
  • Salicylic anhydride, diacetate
  • UNII-XIA5Z82RHB

Applications:

Separation of Acetylsalicylic anhydride on Newcrom R1 HPLC column

May 17, 2018
Separation of Acetylsalicylic anhydride on Newcrom R1 HPLC column

Acetylsalicylic anhydride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Acetylsalicylic anhydride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.