HPLC Method for Analysis of Meclizine on Primesep B Column

Meclizine is a histamine H1 antagonist and a synthetic piperazine. It is used to prevent and treat motion sickness, vertigo, and nausea during pregnancy. The side effects that may occur include drowsiness, dry mouth, and tiredness. The method is UV compatible and can be used as a general approach for analyzing similar compounds.  


Column Primesep B, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 10/90%
Buffer H3PO4 - 0.2 %
Flow Rate 1.0 ml/min
Detection UV, 232 nm


Class of Compounds Drug, Antihistamine, Hydrophobic
Analyzing Compounds Meclizine
Application Analytes: