CAS Number | 50-36-2 |
---|---|
Molecular Formula | C17H21NO4 |
Molecular Weight | 303.358 |
InChI Key | ZPUCINDJVBIVPJ-PFSRBDOWSA-N |
LogP | 2.30 |
Synonyms |
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Applications:
HPLC Method for Analysis of Cocaine
April 29, 2016
Cocaine, also known as coke, is mostly used as a recreational drug. It is a strong stimulant. The drug’s most common appearance in powder form is a salt, usually cocaine hydrochloride. Due to Cocaine rapidly metabolizing in the body, so if it’s ingested/inhaled, its concentration in urine usually does not exceed 10% that of its principal metabolite, benzoylecgonine. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Cocaine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
Column | Primesep 200, 3.2×100 mm, 5 µm, 100A |
Mobile Phase | Gradient MeCN – 5-50% |
Buffer | Gradient H3PO4 – 0.05-0.3%, 5 min, 4 min hold |
Flow Rate | 0.5 ml/min |
Detection | UV, 270 nm |
Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, |
Analyzing Compounds | Cocaine |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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