| CAS Number | 134523-00-5 |
|---|---|
| Molecular Formula | C33H35FN2O5 |
| Molecular Weight | 558.650 |
| InChI Key | XUKUURHRXDUEBC-KAYWLYCHSA-N |
| LogP | 5.04 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Atorvastatin
May 31, 2018
| Column | Newcrom R1 3.2×100 mm, 3 µm, 100A |
| Mobile Phase | MeCN/H2O – 50/50% |
| Buffer | H3PO4 – 0.1 % |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin |
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select optionsLipitor
HPLC Method for Analysis of Lipitor
May 6, 2016
| Column | Primesep 200, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 30-65%, 5 min, 4 min hold |
| Buffer | Gradient H3PO4 0.05 – 0.3% , 5 min, 4 min hold |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Lipitor |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsLipitor
HPLC Separation of Fungicides in a Green Tea Matrix
May 27, 2015
Even though teas are known for containing polyphenols such as catechins, flavonoids and theaflavins, SIELC mixed-mode columns can be used to analyze a matrix from a commercial tea and retain target compounds. In this method, green tea was spiked with 0.005mg/ml of pesticides previously found in teas. Primesep 200 was used for it’s reverse-phase and acidic ion-pairing groups. Target compounds were retained and resolved from the majority of the tea matrix peak.
| Column | Primesep 200, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 50/50% |
| Buffer | H3PO4 – 0.05 % |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Picoxystrobin, Pyrimethanil, Lipitor |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsPicoxystrobin
Pyrimethanil
HPLC Separation of Agricultural Compounds Found in Tea
May 27, 2015
Tea has been known to contain residue of pesticides and fungicides such as picoxystrobin and pyrimethanil. We used Primesep 200, a reversed-phase column with weakly acidic ion-pairing groups to separate picoxystrobin, pyrimethanil and atorvastatin. A 15 minute method used to demonstrate retention control when adjusting ratio of organic to aqueous in the mobile phase. Baseline retention with good resolution was achieved.
| Column | Primesep 200, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 45/55%, MeCN/H2O – 50/50% |
| Buffer | H2SO4 – 0.1 % |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 250 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Picoxystrobin, Pyrimethanil, Lipitor |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsPicoxystrobin
Pyrimethanil
