Trimethyl phosphate

Trimethyl phosphate structural formula

CAS Number512-56-1
Molecular FormulaC3H9O4P
Molecular Weight140.075
  • Trimethyl phosphate
  • Phosphoric acid, trimethyl ester
  • 512-56-1
  • Phosphoric acid, trimethyl ester
  • fosfato de trimetilo
  • Methyl phosphate, (MeO)3PO
  • NSC 58985
  • Phosphate de trimethyle
  • Phosphoric acid trimethyl ester
  • Trimethoxyphosphine oxide
  • Trimethyl orthophosphate
  • Trimethylphosphat
  • EINECS 208-144-8
  • NCI-C03781
  • Phosphate, trimethyl-
  • O,O,O-Trimethyl phosphate
  • Trimethylfosfat
  • TMP
  • TMPA
  • TMPO
  • 91316-44-8


Separation of Trimethyl phosphate on Newcrom R1 HPLC column

February 16, 2018
Separation of Trimethyl phosphate on Newcrom C18 HPLC column

Trimethyl phosphate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Trimethyl phosphate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.