Octamethylcyclotetrasiloxane structural formula

CAS Number556-67-2
Molecular FormulaC8H24O4Si4
Molecular Weight296.616
  • Octamethylcyclotetrasiloxane
  • 2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
  • Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
  • 556-67-2
  • D4
  • Cyclotetrasiloxane, octamethyl-
  • Cyclic dimethylsiloxane tetramer
  • Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
  • Cyclotetrasiloxane,octamethyl
  • Dabco DC 5258
  • Dow Corning 244
  • Dow Corning 344
  • Mirasil CM 4
  • NSC 345674
  • NUC Silicone VS 7207
  • Octamethylcyclotetrasiloxan
  • Octamethylcyclotetrasiloxanes
  • octametilciclotetrasiloxano
  • Silbione 70045V2
  • Silbione V 2
  • Tetracyclomethicone
  • Union Carbide 7207
  • Volasil 244
  • BRN 1787074
  • EINECS 209-136-7
  • Silicone SF 1173
  • Oktamethylcyklotetrasiloxan
  • UNII-CZ227117JE
  • 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
  • 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
  • Oktamethylzyklotetrasiloxan
  • cyclic dimethylsiloxane tetramer
  • 104986-37-0
  • 117563-66-3
  • 1257661-59-8
  • 83874-62-8


Separation of Octamethylcyclotetrasiloxane on Newcrom R1 HPLC column

February 19, 2018
Separation of Octamethylcyclotetrasiloxane on Newcrom C18 HPLC column

Octamethylcyclotetrasiloxane can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.