Hyoscine N-oxide

Hyoscine N-oxide structural formula

CAS Number97-75-6
Molecular FormulaC17H21NO5
Molecular Weight319.357
  • Hyoscine N-oxide
  • (1R,2R,4S,5S,7s)-9-Methyl-9-oxo-3-oxa-9lambda5-azatricyclo[,4~]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (1R,2R,4S,5S)-9-methyl-9-oxido-3-oxa-9-azatricyclo[,4~]non-7-yl ester, (alphaS)-
  • 97-75-6
  • Scopolamine aminoxide
  • 1alpha H,5alpha H-Tropan-3alpha-ol, 6beta,7beta-epoxy-,(-)-tropate (ester), 8-oxide
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-9-oxido-3-oxa-9-azatricyclo[,4]non-7-yl ester, (alpha S)-
  • Genoscopolamine
  • Hyoscinamine oxide
  • Oxicopolamina
  • Scolamine
  • Scolen
  • Scopodex
  • Seamalin
  • Seronex
  • Benzeneacetic acid, alpha-(hydroxymethyl)-,9-methyl-3-oxa-9-azatricyclo[,4]non-7-yl ester, N-oxide,[7(S)-(1alpha,2beta,4beta,5alpha,7beta]-
  • EINECS 202-606-2
  • Hyoscinamide oxide
  • Hyoscineamine oxide
  • Oxicopolamine
  • UNII-0I3054Z711


Separation of Hyoscine N-oxide on Newcrom R1 HPLC column

February 16, 2018
Separation of Hyoscine N-oxide on Newcrom C18 HPLC column

Hyoscine N-oxide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Hyoscine N-oxide
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.