HPLC Method for Analysis of Pamoic acid on Primesep B by SIELC Technologies

Pamoic acid, also known as embonic acid, is a compound with the chemical formula C₂₃H₁₆O₆. It is used in the formation of salts, particularly pamoate salts. The pamoate salts of various drugs are often employed to enhance their solubility, stability, and overall pharmaceutical properties. Pamoic acid itself is characterized by its ability to form stable complexes with a variety of drugs, and these complexes can be more easily processed into pharmaceutical formulations. The use of pamoic acid and its salts is common in the pharmaceutical industry to improve the bioavailability and effectiveness of certain medications. The formation of pamoate salts is a strategy employed in drug development to optimize the therapeutic delivery and performance of various pharmaceutical compounds. You can find detailed UV spectra of Pamoic acid and information about its various lambda maxima by visiting the following link.

Pamoic acid can be retained, and analyzed using a Primesep B mixed-mode stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and sulfuric acid as a buffer. Detection is achieved using UV 235 nm