HPLC Method for Analysis of Molnupiravir on Newcrom R1 Column

Separation type: Liquid Chromatography Reverse Phase.


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High Performance Liquid Chromatography (HPLC) Method for Analysis of Molnupiravir

Molnupiravir is a popular antiviral drug that in hibits RNA replication in certain viruses. It gained recent notoriety in its ability to help treat COVID-19 infections from the SARS-CoV-2 virus. Molnupiravir can be separated and analyzed on a Newcrom R1 reverse-phase column using a simple gradient analytical method with a mobile phase consisting of just Acetonitrile (MeCN) and water (with no ionic modifier). This analysis method can be UV detected at 235 nm with high resolution and peak symmetry.

Condition
Column Newcrom R1, 3.2×100 mm,  100A
Mobile Phase MeCN -15%
Buffer No
Flow Rate 0.5 ml/min
Detection UV 235nm

Description
Class of Compounds Drug
Analyzing Compounds Molnupiravir

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Molnupiravir (EIDD-2801, MK-4482)
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.