HPLC Method for Analysis of Molnupiravir on Newcrom R1 Column

HPLC Method for Molnupiravir (EIDD-2801, MK-4482) on Newcrom R1 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Molnupiravir (EIDD-2801, MK-4482).

Molnupiravir is an antiviral drug with the chemical formula C13H19N3O7. It works through inhibiting RNA replication in viruses like influenza and ebola. It gained recent notoriety in its ability to help treat COVID-19 infections from the SARS-CoV-2 virus. You can find detailed UV spectra of Molnupiravir (EIDD-2801, MK-4482) and information about its various lambda maxima by visiting the following link.

Molnupiravir (EIDD-2801, MK-4482) can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN). Detection is performed using UV.  This analysis method can be UV detected at 235 nm with high resolution and peak symmetry.

Condition
Column Newcrom R1, 3.2 x 100 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN -15%
Buffer No
Flow Rate 0.5 ml/min
Detection UV 235nm

Description
Class of Compounds Drug
Analyzing Compounds Molnupiravir (EIDD-2801, MK-4482)

 

Application Column

Newcrom R1

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Molnupiravir (EIDD-2801, MK-4482)
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.