HPLC Method for Analysis of 1-vinyl-2-pyrrolidone on Newcrom R1 Column by SIELC Technologies
1-Vinyl-2-pyrrolidone, also known as N-vinyl-2-pyrrolidone and NVP, is a chemical compound with the molecular formula C6H9NO. It is a colorless to slightly yellow liquid at room temperature. NVP is a member of the pyrrolidone family and is commonly used as a monomer in the production of various polymers, particularly in the synthesis of polyvinylpyrrolidone (PVP).
NVP is known for its versatility and is utilized in a wide range of applications including pharmaceuticals, personal care products, adhesives, coatings, and as a precursor in the synthesis of specialty chemicals. Its properties, such as solubility in water and various organic solvents, as well as its ability to form hydrogen bonds, make it valuable in these applications. In pharmaceuticals, NVP is used in drug delivery systems, as a binder in tablets, and in topical formulations. In personal care products, it is found in hair care products, skin creams, and dental products due to its film-forming and adhesive properties. Additionally, it is used in adhesives and coatings for its ability to improve adhesion and film formation.
1-vinyl-2-pyrrolidone can be retained and analyzed on a reversed-phase Newcrom R1 column with a mobile phase consisting of water and Acetonitrile (MeCN) This analytical method can be detected with high resolution and peak symmetry at a wavelength of 235 nm using UV detection
Condition
| Column | Newcrom R1, 4.6 x 150 mm, 3 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H20 |
| Buffer | None |
| Flow Rate | 0.5 ml/min |
| Detection | UV 235 nm |
| Injection volume: | 3 µL |
| Sample | 1 mg/ml |
| Sample Diluent | MeCN/H2O – 50/50% |
Description
| Class of Compounds | vinylpyrrolidones |
| Analyzing Compounds | 1-vinyl-2-pyrrolidone |
Application Column
Newcrom R1
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended
