Fluocinolone acetonide

Fluocinolone acetonide structural formula

CAS Number67-73-2
Molecular FormulaC24H30F2O6
Molecular Weight452.495
  • Fluocinolone acetonide
  • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4b,12-difluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-
  • 67-73-2
  • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6?,11?,16?)-
  • 16?,17?-Isopropylidene-6?,9?-difluoro-1,4-pregnadiene-11?,16?,17?,21-tetrol-3,20-dione
  • 6?, 9?-Difluoro-16?-hydroxypredonisolone-16, 17-acetonide
  • 6?,9-Difluoro-11?,16?,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17 acetal with acetone
  • 6?,9-Difluoro-11?,21-dihydroxy-16?,17?-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
  • 6?,9?-Difluoro-11?,16?,17?,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
  • 6?,9?-Difluoro-16?,17?-isopropylidenedioxy-?1-hydrocortisone
  • 6?,9?-Difluoro-16?-hydroxyprednisolone 16,17-acetonide
  • 6?-Fluorotriamcinolone acetonide
  • acetonide de fluocinolone
  • acetonido de fluocinolona
  • Coriphate
  • Cortiplastol
  • Dermalar
  • Dermatin
  • Fluocinolonacetonid
  • Fluocinolone 16,17-acetonide
  • Fluocinolone 16?,17?-acetonide
  • Fluonid
  • Fluovitef
  • Fluovitif
  • Fluvean
  • Localyn
  • Localyn Syntex
  • NSC 92339
  • Percutina
  • Pregna-1,4-diene-3,20-dione, 6?,9-difluoro-11?,16?,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Prodermin
  • Radiocin
  • Retisert
  • Sinalar
  • Synaflan
  • Synalar
  • Synamol
  • Synandone
  • Synandrone
  • Synemol
  • Synotic
  • 6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
  • 6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide
  • EINECS 200-668-5
  • Fluocinolonacetonidum
  • Flupollon
  • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Synalar-HP
  • Tefunote
  • Derma-Smoothe/FS
  • Fluocet
  • Fluotrex
  • Acetonida de fluocinolona
  • Fluocinoloni acetonidum
  • Iluvien
  • 6alpha-fluorotriamcinolone acetonide


Separation of Fluocinolone acetonide on Newcrom R1 HPLC column

February 16, 2018
Separation of Fluocinolone acetonide on Newcrom C18 HPLC column

Fluocinolone acetonide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Fluocinolone acetonide
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.