Diethyl phosphorochloridate

Diethyl phosphorochloridate structural formula

CAS Number814-49-3
Molecular FormulaC4H10ClO3P
Molecular Weight172.540
  • Diethyl phosphorochloridate
  • Phosphorochloridic acid, diethyl ester
  • 814-49-3
  • 4-01-00-01345
  • Phosphorochloridic acid, diethyl ester
  • Chlorodiethoxyphosphine oxide
  • Chlorodiethylphosphate
  • Diethoxyphosphorus oxychloride
  • Diethoxyphosphoryl chloride
  • Diethyl chlorophosphate
  • Diethyl chlorophosphonate
  • Diethyl phosphochloridate
  • Diethyl phosphochoridate
  • Diethyl phosphorochloride
  • Diethylphosphoric acid chloride
  • Diethylphosphorochloridat
  • Ethyl phosphorochloridate
  • Ethyl phosphorochloridate (EtO)2ClPO
  • fosforoclorhidato de dietilo
  • NSC 43770
  • O,O-Diethyl chloridophosphate
  • O,O-Diethyl chlorophosphate
  • O,O-Diethyl chlorophosphonate
  • O,O-Diethyl phosphorochloridate
  • O,O-Diethylphosphoryl chloride
  • Phosphoric acid chloride diethyl ester
  • Phosphorochloridate de diethyle
  • Phosphorochloridic acid diethyl ester
  • BRN 0471433
  • Chlorophosphoric acid, diethyl ester
  • EINECS 212-396-4
  • Phosphine oxide, chlorodiethoxy-
  • Diethylchlorfosfat


Separation of Diethyl phosphorochloridate on Newcrom R1 HPLC column

February 16, 2018
Separation of Diethyl phosphorochloridate on Newcrom C18 HPLC column

Diethyl phosphorochloridate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Diethyl phosphorochloridate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.