Acyclovir

Acyclovir structural formula

CAS Number59277-89-3
Molecular FormulaC8H11N5O3
Molecular Weight225.208
InChI KeyMKUXAQIIEYXACX-UHFFFAOYSA-N
LogP-1.56
Synonyms
  • Acyclovir
  • 2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-
  • 59277-89-3
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-
  • 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
  • 9-(2-Hydroxyethoxymethyl)guanine
  • Acicloftal
  • aciclovir
  • Acyclo V
  • Acycloguanosine
  • Avirase
  • BioVir I
  • BioVir II
  • Cargosil
  • Gerpevir
  • Herpevir
  • Novirus
  • NSC 645011
  • Poviral
  • Rouz-Aciclovir
  • Virorax
  • Virovir
  • Wellcome 248U
  • Zovirax
  • 2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one
  • EINECS 261-685-1
  • 9-((2-Hydroxyethoxy)methyl)guanine
  • Wellcome-248U
  • Hascovir
  • Activir
  • Aciclovirum
  • UNII-X4HES1O11F
  • Sitavig

Applications:

HPLC Method for Simultaneous Determination of Acyclovir and Hydrocortisone on Primesep 100 Column

August 31, 2022

Separation type: Liquid Chromatography Mixed-mode

 

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Acyclovir and Hydrocortisone

Acyclovir is used to treat viral infections caused by a group of viruses called herpes simplex viruses. These infections include oral and genital herpes, as well as shingles. It can also be used to treat chickenpox in children. Hydrocortisone, or cortisol, is a common corticosteroid used to treat a wide variety of ailments, including high blood calcium, arthritis, dermatitis, and asthma, among others. Both of these drugs can be separated, retained, and analyzed on a Primesep 100 mixed-mode column using an isocratic analytical method with a simple isocratic mobile phase of water, Acetonitrile (MeCN), and a sulfuric acid (H2SO4) buffer. This analysis method can be UV detected at 254 nm with high resolution and peak symmetry.

Condition

Column Primesep 100, 3.2×150 mm, 5 µm, 100A
Mobile Phase MeCN – 35%
Buffer H2SO4 – 0.1%
Flow Rate 0.5 ml/min
Detection UV 254 nm

 

Description

Class of Compounds Drug
Analyzing Compounds Acyclovir and Hydrocortisone

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Acyclovir
Hydrocortisone
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Antiviral Drugs on Primesep 100 Column

April 1, 2021

Separation type: Liquid Chromatography Mixed-mode





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High Performance Liquid Chromatography (HPLC) Method for Analysis of Acyclovir, Oseltamivir, Valacyclovir


Unlike antibiotic drugs, which actively destroy their targets, antiviral drugs generally prevent the reproduction of their viral targets. Acyclovir, Valacyclovir, and Oseltamivir are 3 antiviral drugs commonly prescribed to treat viral infections. Acyclovir and Valacyclovir are used to treat viral infections caused by a group of viruses called herpes simplex viruses. These infections include oral and genital herpes, as well as shingles. They can also be used to treat chickenpox in children. Oseltamivir is generally used to help treat (or if taken early enough, prevent) influenza (the flu) infections.
Acyclovir, Valacyclovir, and Oseltamivir can be retained on a Primesep 100 mixed-mode column with great peak shape using acetonitrile (ACN), water and a gradient of sulphuric acid (H2SO4) as a buffer. This method can be UV detected at 200 nm with very high resolution.



Condition

Column Primesep 100, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer Gradient H2SO4 – 0.05- 0.8%, 10 min
Flow Rate 0.5 ml/min
Detection UV, 255 nm

 

Description

Class of Compounds
Drug
Analyzing Compounds Acyclovir, Valacyclovir, Oseltamivir

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Acyclovir
Oseltamivir
Valacyclovir
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Analysis of Acyclovir

August 6, 2015

 

Acyclovir (also spelled aciclover) is an anti-viral drug on the World Health Organization list of essential medicines due to its use in the prevention and treatment of herpes simplex virus, varicella zoster virus and the shingles. Legacy L1 was used to retain aciclovir by reverse phase mechanism. Legacy L1 uses embedded C18 groups on porous silica and is useful for many USP HPLC applications. comparisons to Phenomenex columns are available by request.

Application Column

SIELC Legacy L1 HPLC column

Legacy L1

SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.

Select options
Application Analytes:
Acyclovir

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.