| CAS Number | 29122-68-7 |
|---|---|
| Molecular Formula | C14H22N2O3 |
| Molecular Weight | 266.342 |
| InChI Key | METKIMKYRPQLGS-UHFFFAOYSA-N |
| LogP | 0.16 |
| Synonyms |
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Applications:
Application USP Methods for the Analysis of Atenolol using the Legacy L1 Column
February 20, 2019
Application Column
Legacy L1
SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.
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HPLC Method for Analysis of Atenolol
May 10, 2016
Atenolol a cardioselective beta-1 adrenergic blocker as well as a synthetic isopropylamino-propanol derivative. It belongs to a class of drugs known as beta blockers and is used to treat high blood pressure (hypertension). Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Meclizine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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HPLC Separation of Atenolol on Legacy L1 Column
July 2, 2013
Atenolol is a selective beta receptor antagonist, a drug belonging to beta blockers. The USP method was reproduced on the L1 column. This method can be used for the analysis of atenolol by reversed-phase chromatography on a typical C18 HPLC column. Column and method can be used for other drug substances, intermediates and impurities which need to be analyzed according to the United States Pharmacopeia.
Application Notes: Atenolol is a beta blocker used to treat heart disease as well as thyroid disorders and alcohol withdrawal. The USP HPLC method for the separation of atenolol was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS.
| Column | Primesep 100, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN |
| Buffer | Octanesulfonic Acid, Sulfuric Acid |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Beta blocker, Hydrophobic, Ionizable |
| Analyzing Compounds | Atenolol |
Application Column
Legacy L1
SIELC's family of Legacy columns is based on the United States Pharmacopeia's (USP) published chromatographic methods and procedures. Numerous brands have columns used in USP reference standards and methods. USP has created various designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties, allowing you to easily replace older columns that are no longer available without needing to significantly modify your method or SOPs.
Select options
Primesep 100
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select options
