Pseudoephedrine is a drug used in cough and cold compositions. One of the preservatives in solutions of pseudoephedrine is citric acid. Both compounds are hydrophilic in nature, with pseudoephedrine being a basic compound and citric acid an acidic compound. Separation of these two compounds is achieved on a Primesep N column. Compounds are separated by combination of HILIC, cation-exchange and anion-exclusion mechanisms. Pseudoephedrine and citric acid are monitored by UV. This HPLC method can be adopted as generic approach for analysis of pseudoephedrine and other hydrophilic drugs and preservatives in mixtures.
Application Column
Primesep N
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Application Analytes:
Citric AcidPseudoephedrine (PSE)
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.
