Tamoxifen

Tamoxifen structural formula

CAS Number10540-29-1
Molecular FormulaC26H29NO
Molecular Weight371.524
InChI KeyNKANXQFJJICGDU-QPLCGJKRSA-N
LogP6.24
Synonyms
  • Tamoxifen
  • 2-{4-[(1Z)-1,2-Diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethan-1-amine
  • Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
  • 10540-29-1
  • OHT
  • TAM
  • Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-
  • (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
  • Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
  • Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
  • Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
  • Mammaton
  • Novaldex
  • Tamoxifen and its salts
  • tamoxifene
  • tamoxifeno
  • trans-Tamoxifen
  • Z-Tamoxifen
  • 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
  • (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
  • EINECS 234-118-0
  • 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
  • (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
  • Istubol
  • Tamoxen
  • Valodex
  • Citofen
  • Crisafeno
  • Oncomox
  • Retaxim
  • Tamizam
  • Tamoxifenum
  • UNII-094ZI81Y45

Applications:

Separation of Tamoxifen on Newcrom R1 HPLC column

February 16, 2018
Separation of Tamoxifen on Newcrom C18 HPLC column

amoxifen is a drug that can be used to prevent breast cancer in women and men. Other uses of tamoxifen include treating infertility and gynecomastia. Tamoxifen can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Tamoxifen
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.