Paclitaxel

Paclitaxel structural formula

CAS Number33069-62-4
Molecular FormulaC47H51NO14
Molecular Weight853.919
InChI KeyRCINICONZNJXQF-MZXODVADSA-N
LogP3.65
Synonyms
  • Paclitaxel
  • (2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
  • Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-
  • 33069-62-4
  • Taxol
  • Abraxane
  • BMS 181339-01
  • Ebetaxel
  • Genaxol
  • Genetaxyl
  • Genexol
  • Genexol-PM
  • Mitotax
  • NSC 125973
  • OncoGel
  • Pacliex
  • Plaxicel
  • Tax-11-en-9-one, 5?,20-epoxy-1,2?,4,7?,10?,13?-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
  • TaxAlbin
  • Taxol A
  • Yewtaxan
  • 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
  • NSC-125973
  • Paxceed
  • LipoPac
  • Abraxane I.V. Suspension
  • UNII-P88XT4IS4D
  • Taxus stent
  • Taxus Liberte
  • (NAB)-Paclitaxel
  • Nanoparticle albumin bound paclitaxel
  • Nab-paclitaxel
  • Anzatax
  • Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester,(alphaR,betaS)-Capxol
  • Intaxel
  • cyclopax
  • lipopac
  • onxol
  • paxene

Applications:

Separation of Paclitaxel on Newcrom R1 HPLC column

May 16, 2018
Separation of Paclitaxel on Newcrom R1 HPLC column

Paclitaxel is a chemotherapy medication used to treat cancers. It works by interfering with cell division. Chloramphenicol can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Paclitaxel
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.