Melphalan

Melphalan structural formula

CAS Number148-82-3
Molecular FormulaC13H18Cl2N2O2
Molecular Weight305.200
InChI KeySGDBTWWWUNNDEQ-LBPRGKRZSA-N
LogP-0.520
Synonyms
  • Melphalan
  • 4-[Bis(2-chloroethyl)amino]-L-phenylalanine
  • L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
  • 148-82-3
  • 4-14-00-01689
  • L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
  • 3-[p-bis(2-Chloroethyl)amino]phenylalanine, L-
  • Alanine nitrogen mustard
  • Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-
  • Alanine, 3-[p-bis(2-chloroethyl)amino]phenyl-,L
  • Alkeran
  • Levofalan
  • Levofolan
  • Levopholan
  • L-Phenylalanine mustard
  • L-Phenylalanine mustard hydrochloride
  • L-Phenylalanine, 4-[bis(2-chloroethyl)amino]
  • L-Sarcolysin
  • L-Sarcolysine
  • L-Sarkolysin
  • Melfalan
  • melfalano
  • NSC 241286
  • NSC 8806
  • Phenylalanine mustard
  • Sarcoclorin
  • 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine
  • BRN 2816456
  • EINECS 205-726-3
  • NCI-C04853
  • NSC-8806
  • L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine
  • RCRA waste number U150
  • Melphalanum
  • UNII-Q41OR9510P
  • 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine
  • 4-(Bis(2-chloroethyl)amino)-L-phenylalanine
  • L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
  • L-PAM
  • L-Phenylalanine mustard
  • Phenylalanine nitrogen mustard
  • p-Bis(beta-chloroethyl)aminophenylalanine
  • p-Di-(2-chloroethyl)amino-L-phenylalanine
  • p-L-Sarcolysin
  • p-N,N-bis(2-chloroethyl)amino-L-phenylalanine
  • p-N-Bis(2-chloroethyl)amino-L-phenylalanine
  • 8057-25-8

Applications:

Separation of Melphalan on Newcrom R1 HPLC column

February 16, 2018
Separation of Melphalan on Newcrom C18 HPLC column

Melphalan can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Melphalan
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.