Warfarin is a medication that is also known as “blood thinner". It is used to treat and prevent blood clots. Blood clots can heighten the risk of a stroke or a heart attack which could be fatal. Newcrom R1, a column that takes advantage of the newest technologies, does not contain embedded acidic nor basic ionizable groups and can retain Warfarin. The method is UV compatible and can be used as a general approach for analyzing similar compounds.