HPLC Method For Analysis Of Ubrogepant in UBRELVY® Tablets on Newcrom R1 Column

Ubrogepant, also known as Ubrelvy®, is a newly discovered, calcitonin gene-related peptide receptor (CGPR) antagonist that is used for the acute treatment of migraine headaches. Ubrogepant can be retained and analyzed on a Newcrom R1 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and no buffer. This analysis method can be UV detected at 285 nm with high resolution and peak symmetry.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ubrogepant
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.