Methylamine

CAS Number	74-89-5
Molecular Formula	CH5N
Molecular Weight	31.059
InChI Key	BAVYZALUXZFZLV-UHFFFAOYSA-N
LogP	-0.570
Synonyms	Methylamine Methanamine 74-89-5 Methanamine0 Methanamine Carbinamine Methylamin metilamina, en disolucion acuosa Monomethylamine UN 1061 UN 1235 AI3-15637-X Anhydrous Methylamine EINECS 200-820-0 UNII-BSF23SJ79E CH3-NH2 Imizin MMA MeNH2 Mercurialin Methyl group Methyl of gamma-N-methylasparagine Methylamine anhydrous Methylamine aqueous solution Methylamine solution Methylamine solutions Methylaminen Metilamine Metyloamina N-Methylamine NMA NME aminomethane 119775-09-6 1391413-98-1 42939-70-8 85404-17-7

Applications:

Mixed-Mode Retention and Separation of Ammonia, Primary and Secondary Amines on Primesep A Column

December 6, 2007

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Separation type: Liquid Chromatography Mixed-mode

Ammonia, primary and secondary amines are common compounds used as building blocks in organic synthesis. Derivatives of these compounds are used in agriculture, pharmaceutical, and chemical manufacturing. All compounds in this application are basic and hydrophilic in nature. Problems in analysis include poor peak shape, lack of retention on C18 columns, and absence of chromophores in ammonia, primary and secondary amines. Analysis of hydrophilic amines requires derivatization to provide hydrophobicity/retention and UV activity, ion-pairing reagents to provide retention. Presence of residual silanols will affect peak shape. Ammonia, methylamine, morpholine, ethylamine, diethylamine, and butylamine can be analyzed on a Primesep A HPLC column with trifluoroacetic acid in the mobile phase. Compounds in the mixture can be monitored by ELSD.

Application Column

Primesep A

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Ammonia
Butylamine
Diethylamine
Ethylamine
Methylamine
Morpholine

ELSD Detection

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Simple Amines and Ammonia

October 4, 2006

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Primesep A separates ammonia and simple amines (butylamine, diethylamine, ethylamine, methylamine and morpholine) by cation exchange and reversed phase. Primesep A has an embedded strong anionic functional group which helps retain cations by polar and ion-exchange mechanisms. Excellent peak shape results with a mass spec compatible mobile phase of water, acetonitrile (MeCN, ACN) and trifluoracetic acid (TFA) with evaporative light scattering detection (ELSD).