Cimetidine

Cimetidine structural formula

CAS Number51481-61-9
Molecular FormulaC10H16N6S
Molecular Weight252.340
InChI KeyAQIXAKUUQRKLND-UHFFFAOYSA-N
LogP0.4
Synonyms
  • Cimetidine
  • N''-Cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
  • Guanidine, N''-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-
  • 51481-61-9
  • Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-
  • Acibilin
  • Cimetag
  • Cimetidin
  • cimetidina
  • Cimetum
  • Dyspamet
  • Edalene
  • Eureceptor
  • Gastromet
  • Guanidine, N-cyano-N'-methyl-N''-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-
  • Histodil
  • N-Cyano-N'-methyl-N''-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine
  • NSC 335308
  • Tagamet
  • Tametin
  • Ulcedin
  • Ulcerfen
  • Ulcimet
  • Ulcofalk
  • Ulcomedina
  • Ulcomet
  • N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine
  • 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine
  • EINECS 257-232-2
  • Guanidine, N-cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio) ethyl)-
  • Metracin
  • Ulcedine
  • Tagamet HB 200
  • Valmagen
  • Ulcestop
  • Gastrobitan
  • Tagamet HB
  • Cimetidinum
  • UNII-80061L1WGD
  • Topcare heartburn relief
  • Equaline acid reducer
  • 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine
  • N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine
  • N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine

Applications:

Separation of Cimetidine on Newcrom R1 HPLC column

February 16, 2018
Separation of Cimetidine on Newcrom C18 HPLC column

Cimetidine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Cimetidine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.