| CAS Number | 93-97-0 |
|---|---|
| Molecular Formula | C14H10O3 |
| Molecular Weight | 226.232 |
| InChI Key | CHIHQLCVLOXUJW-UHFFFAOYSA-N |
| LogP | 2.26 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride on Newcrom R1 Column
June 3, 2022
Separation type: Liquid Chromatography Reverse Phase.
High Performance Liquid Chromatography (HPLC) Method for Analysis of Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride
Acetic Anyhydride is a common reagent in organic synthesis, particularly in the acetylation of alcohols, amines, and aromatic rings. Benzyl Alcohol is a popular organic solvent and preservative used in topical drugs, cosmetics, and intravenous drugs. Benzoic Anhydride is the anhydride form of Benzoic Acid and a common reagent in organic synthesis. These 3 organic compounds can be separated and analyzed on a Newcrom R1 reverse-phase column using a simple gradient analytical method with a mobile phase consisting of just water and Acetonitrile (MeCN) (with no ionic modifier). This analysis method can be UV detected at 200 or 275 nm with high resolution and peak symmetry.
| Column | Newcrom R1, 3.2×100 mm, 100A |
| Mobile Phase | Gradient MeCN – 20-100% |
| Buffer | No |
| Flow Rate | 0.5 ml/min |
| Detection | UV 200, 275nm |
| Class of Compounds | Acid, Hydrophilic |
| Analyzing Compounds | Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride |
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select optionsBenzoic anhydride
Benzyl alcohol
HPLC Method For Analysis Of Benzoic Anhydride on Primesep S2 Column
February 1, 2022
Separation type: Liquid Chromatography HILIC
Benzoic Anhydride is a derivative of Benzoic acid and a common benzoylation agent used in the pharmaceutical industry and a common reagent for synthesizing benzoic esters. Benzoic Anhydride can be retained and analyzed on a mixed-mode Primesep S2 column with a mobile phase consisting of just Acetonitrile (MeCN) without water or a buffer. This analytical method can be UV detected at 210 nm with high resolution and peak symmetry.
High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzoic Anhydride
| Column | Primesep S2, 4.6×250 mm, 5 µm, 100A |
| Mobile Phase | MeCN- 100% |
| Buffer | No |
| Flow Rate | 1.0 ml/min |
| Detection | UV 210 nm |
| Class of Compounds | Anhydride |
| Analyzing Compounds | Benzoic Anhydride |
Application Column
Primesep S2
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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HPLC Determination of Benzoic Anhydride on Newcrom R1 Column
July 26, 2021
Separation type: Liquid Chromatography Reverse Phase.
High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzoic Anhydride.
Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. Benzoic anhydride is used as a benzoylating agent in the manufacture of pharmaceuticals, intermediates and dyes. Benzoic Anhydride can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN), water and detected by UV, ELSD, CAD or LC/MS.
| Column | Newcrom R1, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN – 70% |
| Buffer | No |
| Flow Rate | 1.0 ml/min |
| Detection | 275 nm |
| Class of Compounds | Hydrophobic |
| Analyzing Compounds | Benzoic Anhydride |
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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Separation of Benzoic anhydride on Newcrom R1 HPLC column
February 16, 2018
Benzoic anhydride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select options