HPLC Determination of Benzoic Anhydride on Newcrom R1 Column

Separation type: Liquid Chromatography Reverse Phase.


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High Performance Liquid Chromatography (HPLC) Method for Analysis of  Benzoic Anhydride.

Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. Benzoic anhydride is used as a benzoylating agent in the manufacture of pharmaceuticals, intermediates and dyes. Benzoic Anhydride can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN), water and detected by UV, ELSD, CAD or LC/MS.


Column Newcrom R1, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN – 70%
Buffer No
Flow Rate 1.0 ml/min
Detection 275 nm


Class of Compounds Hydrophobic
Analyzing Compounds Benzoic Anhydride


Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Benzoic anhydride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.