Tizanidine

Tizanidine structural formula
UV Spectra of Tizanidine

CAS Number51322-75-9
Molecular FormulaC9H8ClN5S
Molecular Weight253.711
InChI KeyXFYDIVBRZNQMJC-UHFFFAOYSA-N
LogP1.32
Synonyms
  • Tizanidine
  • 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
  • 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
  • 51322-75-9
  • 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
  • 2,1,3-Benzothiadiazole-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
  • BRN 0618691
  • 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
  • Sirdalud
  • Ternelin
  • Tizanidina
  • Tizanidinum
  • UNII-6AI06C00GW

Applications:

HPLC Method for Analysis of Tizanidine in Pharmaceutical Dosage Form

August 1, 2018

HPLC Method for Separation of Tizanidine on Primesep 200 by SIELC Technologies

HPLC Method for Analysis of Tizanidine in Pharmaceutical Dosage Form by SIELC Technologies

Tizanidine, marketed under the brand name Sirdalud among others, is a medication primarily used to manage spasticity, a condition where muscles are continuously contracted, causing stiffness or tightness of the muscles, interfering with normal movement, speech, and gait. It is commonly associated with conditions like multiple sclerosis and spinal cord injury.

Tizanidine works by blocking nerve impulses to the brain, relaxing the muscles and thereby relieving symptoms of spasticity.

However, tizanidine can have significant side effects, and it’s important that it is used under the supervision of a healthcare provider. Side effects can include hypotension (low blood pressure), dry mouth, weakness, drowsiness, and in some cases, liver injury.

In addition, tizanidine can interact with other medications, including certain antidepressants, antibiotics, and blood pressure medications. Therefore, it’s important to tell your healthcare provider about any other medications you’re taking.

Lastly, tizanidine can cause physical dependence, and stopping it suddenly can result in withdrawal symptoms. It should be discontinued gradually under a doctor’s supervision.

This compound can be retained and analyzed on a mixed-mode Primesep 200 column with a mobile phase consisting of water, Acetonitrile (MeCN), and phosphoric acid (H3PSO4). This analytical method can be UV detected at 228 nm with high resolution and peak symmetry.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Tizanidine

ColumnPrimesep 200, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 60/40%
BufferH3PO4 – 0.2 %
Flow Rate1.0 ml/min
DetectionUV, 228 nm
Class of Compounds
Drug, Basic, Hydrophobic, Ionizable
Analyzing CompoundsTizanidine

Application Column

Primesep 200

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Tizanidine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.