Quinine

CAS Number	130-95-0
Molecular Formula	C20H24N2O2
Molecular Weight	324.424
InChI Key	LOUPRKONTZGTKE-WZBLMQSHSA-N
LogP	3.44
Synonyms	Quinine (8alpha,9R)-6'-Methoxycinchonan-9-ol Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)- 130-95-0 Cinkona Mosgard Qualaquin Quine 9 Quinex Quinlex Quinlup Rezquin Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)- (-)-Quinine (8S,9R)-Quinine (8α,9R)-6'-Methoxycinchonan-9-ol (R)-(-)-Quinine 6'-Methoxycinchonidine Chinine NSC 192949 quinina EINECS 205-003-2 (8-alpha,9R)-6'-Methoxycinchonan-9-ol 6-Methoxycinchonine Quinine anhydrous 2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl- (R)-(-)-Quinine, 6-methoxycinchonidine UNII-A7V27PHC7A (R)-(6-Methoxy-quinolin-4-yl)-((2S,5S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol (R)-(6-methoxy-quinolin-4-yl)-((2S,5S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol Chinin chininum 1071756-51-8 12239-42-8 128544-03-6 21480-31-9 55980-20-6 6912-57-8 72646-90-3 767303-40-2 840482-04-4 857212-53-4 864908-93-0 875538-34-4 888714-03-2 890027-24-4 894767-09-0 898813-59-7 898814-28-3 899813-83-3 900786-66-5 900789-95-9 906550-97-8 909263-47-4 909767-48-2 909882-78-6 910878-25-0 910880-97-6 911445-75-5 918778-04-8 95650-40-1 1628705-47-4 1267651-57-9

Applications:

HPLC Separation of Quinine and Quinidine

October 11, 2010

View Application

Quinine and quinidine are diastereomers. Quinine is an alkaloid with fever-reducing analgetic and anti-inflammatory properties. Both compounds have the same structure, and the only difference is optical position at two centers. These two diastereomers were separated on achiral mixed-mode cation-exclusion Primesep B column. No separation is observed on traditional achiral reversed-phase column. This examples shows that even diastereomers can be separated on mixed-mode HPLC columns.

Application Column

Primesep B

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Hydroquinidine
Quinidine
Quinine

UV Detection

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