Quinidine

Quinidine structural formula

CAS Number56-54-2
Molecular FormulaC20H24N2O2
Molecular Weight324.424
InChI KeyLOUPRKONTZGTKE-LHHVKLHASA-N
LogP3.44
Synonyms
  • Quinidine
  • (9S)-6'-Methoxycinchonan-9-ol
  • Cinchonan-9-ol, 6'-methoxy-, (9S)-
  • 56-54-2
  • Cinchonan-9-ol, 6'-methoxy-, (9S)-
  • (+)-Quinidine
  • (8R,9S)-Quinidine
  • 6-Methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
  • Chinidin
  • Cin-quin
  • Conchinin
  • Conchinine
  • Conquinine
  • Kinidin
  • Pitayin
  • Pitayine
  • quinidina
  • Quinidine, (+)-
  • β-Quinidine
  • β-Quinine
  • EINECS 200-279-0
  • (9S)-6'-Methoxycinchonan-9-ol
  • alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (9S)-
  • (9S)-6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
  • NCI-C56246
  • UNII-ITX08688JL
  • (S)-(6-methoxy-4-quinolyl)-[(2R,4S,5R)-5-vinyl-2-quinuclidinyl]methanol
  • (S)-(6-methoxy-4-quinolyl)-[(2R,4S,5R)-5-vinylquinuclidin-2-yl]methanol
  • (S)-[(4S,5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol
  • 6-methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
  • alpha-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
  • beta-quinine
  • chinidinum
  • 11010-73-4
  • 500225-45-6
  • 845886-64-8
  • 882741-47-1
  • 883881-01-4
  • 898814-00-1
  • 910899-51-3
  • 1528764-92-2

Applications:

HPLC Separation of Quinine and Quinidine

October 11, 2010


Quinine and quinidine are diastereomers. Quinine is an alkaloid with fever-reducing analgetic and anti-inflammatory properties. Both compounds have the same structure, and the only difference is optical position at two centers. These two diastereomers were separated on achiral mixed-mode cation-exclusion Primesep B column. No separation is observed on traditional achiral reversed-phase column. This examples shows that even diastereomers can be separated on mixed-mode HPLC columns.

Application Column

Primesep B

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Hydroquinidine
Quinidine
Quinine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.