Ciclopirox

Ciclopirox structural formula

CAS Number29342-05-0
Molecular FormulaC12H17NO2
Molecular Weight207.273
InChI KeySCKYRAXSEDYPSA-UHFFFAOYSA-N
LogP2.37
Synonyms
  • Ciclopirox
  • 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one
  • 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-
  • 29342-05-0
  • 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-
  • 2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-
  • EINECS 249-577-2
  • Loprox Gel
  • Loprox cream
  • Ciclopirox gel
  • Ciclopiroxum
  • UNII-19W019ZDRJ
  • 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone

Applications:

HPLC Determination of Ciclopirox on Newcrom A Column

July 28, 2020


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Condition
Column Newcom A, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN – 45%
Buffer HClO4 – 0.2%
Flow Rate 1.0 ml/min
Detection UV 300 nm

Description
Class of Compounds Drug, Synthetic antifungal agent
Analyzing Compounds Ciclopirox

 

Application Column

Newcrom A

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ciclopirox
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Ciclopirox on Newcrom R1 HPLC column

May 16, 2018
Separation of Ciclopirox on Newcrom R1 HPLC column

Ciclopirox can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Ciclopirox
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.