Methylprednisolone succinate

Methylprednisolone succinate structural formula

CAS Number2375-03-3
Molecular FormulaC26H33NaO8
Molecular Weight496.533
InChI KeyFQISKWAFAHGMGT-SGJOWKDISA-M
LogP1.67
Synonyms
  • Methylprednisolone succinate
  • Sodium 4-{[(6alpha,11beta)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoate
  • Butanedioic acid, mono[(6alpha,11beta)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl] ester, sodium salt (1:1)
  • 2375-03-3
  • EINECS 219-156-8
  • 6alpha-Methylprednisolone 21-hemisuccinate sodium salt
  • Methylprednisolone sodium hemisuccinate
  • 6alpha-Methylprednisolone sodium hemisuccinate
  • 6alpha-Methylprednisolone 21-sodium hemisuccinate
  • 6-alpha-Methylprednisolone sodium succinate
  • 6alpha-Methylprednisolone sodium succinate
  • 6alpha-Methylprednisolone 21-sodium succinate
  • Methylprednisolone succinate sodium salt
  • 6alpha-Methylpregnisolone 21-sodium succinate
  • NSC 48989
  • Prednisolone, 6alpha-methyl-, succinate, sodium salt
  • Solu-Medrone
  • 11-beta,17,21-Trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione 21-(sodium succinate)
  • Urbason solubile
  • Succinic acid, 21-monoester with 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione, monosodium salt
  • Metypred
  • Sodium methylprednisolone succinate
  • Asmacortone
  • Corticel
  • Emmetipi
  • Firmacort Fiale
  • Lemod Solu
  • Metypresol
  • Nirypan solubile
  • Prednilem
  • Sol Melcort
  • Cryosolona
  • Prednol
  • Ubrason solubile
  • UNII-LEC9GKY20K
  • Omnacortil

Applications:

Separation of Methylprednisolone succinate on Newcrom R1 HPLC column

February 16, 2018
Separation of Methylprednisolone succinate on Newcrom C18 HPLC column

Methylprednisolone succinate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Methylprednisolone succinate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.