Folinic acid

Folinic acid structural formula

CAS Number58-05-9
Molecular FormulaC20H23N7O7
Molecular Weight473.446
InChI KeyVVIAGPKUTFNRDU-ABLWVSNPSA-N
LogP-2.82
Synonyms
  • Folinic acid
  • N-(4-{[(2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
  • L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
  • 58-05-9
  • Leucovorin
  • L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
  • (6R,S)-5-Formyltetrahydrofolate
  • 10-Formyl-7,8-dihydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydrofolic acid
  • 5-formyltetrahydrofolic acid
  • 5-Formyltetrahydrofolsaure
  • 5-Formyltetrahydropteroylglutamic acid
  • acide 5-formyltetrahydrofolique
  • acido 5-formiltetrahidrofolico
  • Folinic acid-SF
  • Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
  • Leucoverin
  • L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
  • l-Leucovorin
  • N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • N5-Formyltetrahydrofolic acid
  • Welcovorin
  • EINECS 200-361-6
  • UNII-Q573I9DVLP
  • (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
  • 10-Formyl-7,8-dihydrofolate
  • 2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
  • 5-Formyl-5,6,7,8-tetrahydrofolate
  • 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
  • 5-Formyltetrahydrofolic acid
  • 5-Formyltetrahydropteroylglutamate
  • Acide folinique
  • L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
  • Leucal
  • Leucovorinum
  • N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
  • N5-Formyl-5,6,7,8-tetrahydrofolate
  • N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • N5-Formyltetrahydrofolate

Applications:

Separation of Folinic acid on Newcrom R1 HPLC column

February 16, 2018
Separation of Folinic acid on Newcrom C18 HPLC column

Folinic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Folinic acid
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.