| CAS Number | 49562-28-9 |
|---|---|
| Molecular Formula | C20H21ClO4 |
| Molecular Weight | 360.830 |
| InChI Key | YMTINGFKWWXKFG-UHFFFAOYSA-N |
| LogP | 4.71 |
| Synonyms |
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Applications:
HPLC Separation of Fenofibric Acid and Fenofibrate on Primesep 100 Column
September 1, 2021
Separation type: Liquid Chromatography Mixed-mode
| Column | Primesep 100, 2.1×100 mm, 2.7 µm, 100A |
| Mobile Phase | MeCN – 60% |
| Buffer | Formic Acid – 0.05% |
| Flow Rate | 0.2 ml/min |
| Detection | UV, 286 nm |
| Column | Newcrom AH, 3.2×100 mm, 3 µm, 100A |
| Mobile Phase | MeCN – 45% |
| Buffer | Formic Acid – 0.05% |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 286 nm |
| Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, Supplements |
| Analyzing Compounds | Fenofibrate, Fenofibric Acid |
Application Column
Newcrom AH
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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Primesep 100
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsFenofibric acid
HPLC Method for Analysis of Fenofibric Acid and Fenofibrate on Primesep 200 column
May 10, 2016
Fenofibrate is a synthetic Peroxisome Proliferator Receptor alpha (PPAR alpha) Agonist as well as an antilipemic agent. It is used to help lower “bad” cholesterol and fats (LDL, triglycerides) by increasing the natural enzyme that breaks down fats in the blood. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Propranolol. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
| Column | Primesep 200, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | MeCN – 45% |
| Buffer | H2SO4 – 0.05%, |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 286 nm |
| Class of Compounds |
Drug, Acid, Hydrophilic, Ionizable, Supplements |
| Analyzing Compounds | Fenofibrate |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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