Ethacrynic acid

Ethacrynic acid structural formula

CAS Number58-54-8
Molecular FormulaC13H12Cl2O4
Molecular Weight303.141
InChI KeyAVOLMBLBETYQHX-UHFFFAOYSA-N
LogP3.33
Synonyms
  • Ethacrynic acid
  • [2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
  • Acetic acid, 2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-
  • 58-54-8
  • Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-
  • [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid
  • [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid
  • [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid
  • 2,3-Dichloro-4-(2-ethyl-1-oxo-2-propenyl)-phenoxyacetic acid
  • Acetic acid, [2,3-dichloro-4-(2-methylenebutyryl)phenoxy]-
  • Acetic acid, 2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-
  • acide etacrynique
  • acido etacrinico
  • Crinuril
  • Edecril
  • Edecrin
  • Edecrina
  • Endecril
  • etacrynic acid
  • Etacrynsaure
  • Etakrinic acid
  • Hidromedin
  • Hydromedin
  • NSC 624008
  • NSC 85791
  • Otacril
  • Taladren
  • BRN 1915060
  • Crinuryl
  • 2,3-Dichloro-4-(2-methylenebutyl)phenoxyacetic acid
  • 2,3-Dichloro-4-(2-methylenebutyryl)phenoxy acetic acid
  • (2,3-Dichloro-4-(2-methylenebutyryl)phenoxy)acetic acid
  • (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid
  • EINECS 200-384-1
  • Methylenebutyryl phenoxyacetic acid
  • (4-(2-Methylenebutyryl)-2,3-dichlorophenoxy)acetic acid
  • Methylenebutyrylphenoxyacetic acid
  • Acidum etacrynicum
  • Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova
  • Kyselina ethakrynova
  • UNII-M5DP350VZV
  • 2-[2,3-dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid
  • 2-[2,3-dichloro-4-(2-methylene-1-oxo-butyl)phenoxy]acetic acid
  • 2-[2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid
  • 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
  • 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]ethanoic acid
  • Etacrinic acid
  • Ethacrynate
  • Methylenebutyrylphenoxyacetic acid

Applications:

Separation of Ethacrynic acid on Newcrom R1 HPLC column

February 16, 2018
Separation of Ethacrynic acid on Newcrom C18 HPLC column

Ethacrynic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ethacrynic acid
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.