Ephedrine

Ephedrine structural formula

CAS Number299-42-3
Molecular FormulaC10H15NO
Molecular Weight165.236
InChI KeyKWGRBVOPPLSCSI-WPRPVWTQSA-N
LogP0.552
Synonyms
  • Ephedrine
  • (1R,2S)-2-(Methylamino)-1-phenylpropan-1-ol
  • Benzenemethanol, alpha-[(1S)-1-(methylamino)ethyl]-, (alphaR)-
  • 299-42-3
  • L-Ephedrine
  • Benzenemethanol, ?-[(1S)-1-(methylamino)ethyl]-, (?R)-
  • (-)-(1R,2S)-Ephedrin
  • (-)-Ephedrin
  • (-)-Ephedrine
  • (-)-erythro-Ephedrine
  • (1R,2S)-(-)-Ephedrine
  • (1R,2S)-1-Hydroxy-2-(methylamino)-1-phenylpropane
  • (1R,2S)-2-(Methylamino)-1-phenyl-1-propanol
  • (1R,2S)-Ephedrine
  • (?R)-?-[(1S)-1-(Methylamino)ethyl]benzenemethanol
  • 1(R),2(S)-erythro-(-)-Ephedrine
  • Benzenemethanol, ?-[1-(methylamino)ethyl]-, [R-(R*,S*)]-
  • Benzenemethanol, ?-[1-(methylamino)ethyl]-,[R-(R*,S*)]-
  • efedrina
  • Ephedrin
  • Ephedrine, (-)-
  • L-erythro-2-(Methylamino)-1-phenyl-1-propanol
  • L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
  • NSC 170951
  • NSC 8971
  • Xenadrine
  • Biophedrin
  • Eciphin
  • Efedrin
  • EINECS 206-080-5
  • Ephedremal
  • L(-)-Ephedrine
  • Ephedrital
  • Ephedrol
  • Ephedrosan
  • Ephedrotal
  • Ephedsol
  • Ephendronal
  • Ephoxamin
  • alpha-Hydroxy-beta-methyl amine propylbenzene
  • 1-Hydroxy-2-methylamino-1-phenylpropane
  • alpha-Hydroxy-beta-methylaminopropylbenzene
  • Kratedyn
  • Lexofedrin
  • Manadrin
  • Mandrin
  • alpha-(1-(Methylamino)ethyl)benzenemethanol
  • l-alpha-(1-Methylaminoethyl)benzyl alcohol
  • (-)-alpha-(1-Methylaminoethyl)benzyl alcohol
  • 1-alpha-(1-Methylaminoethyl)benzyl alcohol
  • l-2-Methylamino-1-phenylpropanol
  • 1-2-Methylamino-1-phenylpropanol
  • 2-Methylamino-1-phenyl-1-propanol
  • Norephedrine, N-methyl-
  • 1-Phenyl-1-hydroxy-2-methylaminopropane
  • 1-Phenyl-2-methylaminopropanol
  • i-Sedrin
  • Vencipon
  • Zephrol
  • UNII-GN83C131XS
  • Sal-Phedrine
  • 321-96-0
  • 6912-63-6

Applications:

Separation of Ephedrine on Newcrom R1 HPLC column

February 16, 2018
Separation of Ephedrine on Newcrom C18 HPLC column

Ephedrine is a stimulant that is often used to prevent low blood pressure during spinal anesthesia. It is occasionally used to treat asthma, narcolepsy, and obesity. Ephedrine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ephedrine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.