Disulfamide

Disulfamide structural formula

CAS Number671-88-5
Molecular FormulaC7H9ClN2O4S2
Molecular Weight284.731
InChI KeyRCFKEIREOSXLET-UHFFFAOYSA-N
LogP0.186
Synonyms
  • Disulfamide
  • 4-Chloro-6-methylbenzene-1,3-disulfonamide
  • 1,3-Benzenedisulfonamide, 4-chloro-6-methyl-
  • 671-88-5
  • 4-11-00-00559
  • BRN 2702245
  • 5-Chloro-2,4-disulfamoyltoluene
  • 5-Chloro-2,4-disulfamyltoluene
  • 4-Chloro-6-methyl-1,3-benzenedisulfonamide
  • Desamide
  • Disamide
  • Disulphamide
  • Diuroblitz
  • EINECS 211-585-9
  • Fisiuretik
  • Natirene 25
  • NSC 38904
  • Tolclotidum
  • Toluidrin
  • Toluren
  • 1,3-Benzenedisulfonamide, 4-chloro-6-methyl-
  • Toluene-2,4-disulfamoyltoluene
  • Diurex
  • Disulfamida
  • Disulfamidum
  • UNII-26POQ4GICP

Applications:

Separation of Disulfamide on Newcrom R1 HPLC column

May 17, 2018

Separation of Disulfamide on Newcrom R1 HPLC column

In the human body, disulfamide inhibits benzenedisulfonamide and carbonic anhydrase (CA). This causes diuresis as the inhibition of carbonic anhydrase prevents the reabsorption of water by the kidneys. Disulfamide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications, the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Disulfamide
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.