Diltiazem hydrochloride

Diltiazem hydrochloride structural formula

CAS Number33286-22-5
Molecular FormulaC22H27ClN2O4S
Molecular Weight450.981
InChI KeyHDRXZJPWHTXQRI-BHDTVMLSSA-N
LogP3.01
Synonyms
  • Diltiazem hydrochloride
  • (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate--hydrogen chloride (1/1)
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, hydrochloride (1:1)
  • 33286-22-5
  • QT Drugs
  • Altiazem
  • Anginyl
  • Angizem
  • Britiazim
  • Calcicard
  • Dilpral
  • Diltiazem chloridrate
  • EINECS 251-443-3
  • Herbesser
  • Tildiem
  • Cardizem CD
  • Taztia XT
  • Adizem-CD
  • Altiazem Retard
  • Altiazem RR
  • Angitil
  • Apo-diltiazem
  • Bi-Tildiem
  • Calnurs
  • Cardiazem
  • Cardil Retard
  • Cardizem Retard
  • Cirilen
  • Cirilen AP
  • Citizen
  • Clarute
  • Corazet
  • Deltazen
  • Dilacor
  • Diladel
  • Dilatam
  • Dilatam 120
  • Dilatame
  • Dilcard
  • Dilgard
  • Dilicardin
  • Dilrene
  • Dil-Sonaramia
  • Diltahexal
  • Diltan SR
  • Diltelan
  • Diltiasyn
  • Diltiazem AWD
  • Diltiazem Basics
  • Diltiazem Eu Rho
  • Diltiazem GNR
  • Diltiazem Henning
  • Diltiazem Merck
  • Diltiazem MSD
  • Diltiazem Stada
  • Diltiazem UPSA
  • Diltiazem Verla
  • Diltiazem-Cophar
  • Diltiazem-GRY
  • Diltiazem-Isis
  • Diltiazem-Mepha
  • Diltikor
  • Diltime
  • Dilzem RR
  • Dilzene
  • Dilzereal 90 Retard
  • Dilzicardin
  • Dinisor
  • Dinisor Retard
  • Dodexen
  • Dodexen A.P.
  • Entrydil
  • Farmabes
  • Gadoserin
  • Helsibon
  • Herbesser 180 SR
  • Herbesser 60
  • Herbesser 90 SR
  • Incoril
  • Kaltiazen
  • Lacerol
  • Levozem
  • Longazem
  • Lytelsen
  • Metazem
  • Miocardie
  • Mono-Tildiem
  • Myonil Retard
  • Novo-Diltazem
  • Oxycardil
  • Pazeadin
  • Pentilzeno
  • Poltiazem
  • Presoken
  • Presokin A. P.
  • Surazem
  • Syn-Diltiazem
  • Tilazem
  • Tilazem AS 60
  • Tilazem AS 90
  • Tildiem CR
  • Tildiem LA
  • Tildiem Retard
  • Trumsal
  • Uni Masdil
  • Viazem SR
  • Viazem XL
  • WL Diltiazem
  • Ziruvate
  • Cardizem SR
  • Dilt-CD
  • Diltzac
  • Dilt-XR
  • Tiazac extended release
  • Diltia XT
  • UNII-OLH94387TE
  • (+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester monohydrochloride
  • (2S-cis)-3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride
  • 2-[(2S,3S)-3-(acetyloxy)-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl]-N,N-dimethylethanaminium chloride
  • Diltiazem hydrochloride
  • diltiazem HCl

Applications:

Separation of Diltiazem hydrochloride on Newcrom R1 HPLC column

May 16, 2018
Separation of Diltiazem hydrochloride on Newcrom R1 HPLC column

Diltiazem hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Diltiazem hydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.