Decitabine

Decitabine structural formula

CAS Number2353-33-5
Molecular FormulaC8H12N4O4
Molecular Weight228.208
InChI KeyXAUDJQYHKZQPEU-KVQBGUIXSA-N
LogP-1.89
Synonyms
  • Decitabine
  • 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
  • 2353-33-5
  • 5-aza-2'-deoxycytidine
  • 5A2dc
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-?-D-erythro-pentofuranosyl)-
  • 2'-Deoxy-5-azacytidine
  • 2-Desoxy-5-azacytidine
  • 4-amino-1-(2-deoxy-?-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
  • 4-amino-1-(2-desoxi-?-D-erythro-pentofuranosil)-1,3,5-triazin-2(1H)-ona
  • 4-amino-1-(2-desoxy-?-D-erythro-pentofurannosyl)-1,3,5-triazine-2(1H)-one
  • 4-Amino-1-(2-desoxy-?-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-on
  • 5-Azadeoxycytidine
  • Dacogen
  • NSC 127716
  • s-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-?-D-erythro-pentofuranosyl)-
  • 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one
  • BRN 0617982
  • EINECS 219-089-4
  • 2-Deoxyazacytidine
  • UNII-776B62CQ27
  • 5-Aza-deoxycytidine

Applications:

Separation of Decitabine on Newcrom R1 HPLC column

February 19, 2018
Separation of Decitabine on Newcrom C18 HPLC column

Decitabine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Decitabine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.