Chlortetracycline hydrochloride

Chlortetracycline hydrochloride structural formula

CAS Number64-72-2
Molecular FormulaC22H24Cl2N2O8
Molecular Weight515.341
InChI KeyCBHYYLPALVVVEY-MRFRVZCGSA-N
LogP-0.513
Synonyms
  • Chlortetracycline hydrochloride
  • (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide--hydrogen chloride (1/1)
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, hydrochloride (1:1)
  • 64-72-2
  • B-Aureo
  • Aureociclina
  • Aureocycline
  • Aureomycin hydrochloride
  • Aureomycin monohydrochloride
  • Auxeomycin
  • Biomitsin hydrochloride
  • Biomycin hydrochloride
  • Chlorotetracycline hydrochloride
  • 7-Chlorotetracycline hydrochloride
  • 7-Chlorotetracycline monohydrochloride
  • Chlortetracycline, monohydrochloride
  • Chlortetracyclinium chloride
  • Clorocipan
  • EINECS 200-591-7
  • Isphamycin
  • NSC-13252
  • Psittacin hydrochloride
  • Tetracycline, 7-chloro-, hydrochloride
  • Aurofac 100
  • Aureovit 12C80
  • Clorotetraciclina cloridrato
  • UNII-O1GX33ON8R
  • CLTC 100 MR
  • Pennchlor 64

Applications:

Separation of Chlortetracycline hydrochloride on Newcrom R1 HPLC column

February 16, 2018
Separation of Chlortetracycline hydrochloride on Newcrom C18 HPLC column

Chlortetracycline hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Chlortetracycline hydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.