Chloramphenicol base

Chloramphenicol base structural formula

CAS Number716-61-0
Molecular FormulaC9H12N2O4
Molecular Weight212.206
InChI KeyOCYJXSUPZMNXEN-RKDXNWHRSA-N
LogP-0.223
Synonyms
  • Chloramphenicol base
  • (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol
  • 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-
  • 716-61-0
  • EINECS 211-938-7
  • D-threo-(-)-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
  • Levoamine
  • (R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol

Applications:

Separation of Chloramphenicol base on Newcrom R1 HPLC column

May 16, 2018
Separation of Chloramphenicol base on Newcrom R1 HPLC column

Chloramphenicol is an antibiotic that is used to treat a variety of infections, including conjunctivitis. It is only used now if safer antibiotics aren’t effective. Chloramphenicol can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics..

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Chloramphenicol base
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.