Amitriptynol

Amitriptynol structural formula

CAS Number1159-03-1
Molecular FormulaC20H25NO
Molecular Weight295.426
InChI KeyONSQUXZPOPTSQF-UHFFFAOYSA-N
LogP3.17
Synonyms
  • Amitriptynol
  • 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ol
  • 5H-Dibenzo[a,d]cyclohepten-5-ol, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
  • 1159-03-1
  • BRN 2148173
  • 10,11-Dihydro-5-(3-dimethylaminopropyl)-5H-dibenzo(a,d)cyclohepten-5-ol
  • 5-(3-Dimethylaminopropyl)5-dibenzo(a,d)cycloheptadienol
  • EINECS 214-594-6
  • UNII-67H6DX3NOO

Applications:

Separation of Amitriptynol on Newcrom R1 HPLC column

May 16, 2018
Separation of Amitriptynol on Newcrom R1 HPLC column

Amitriptynol is a drug. It is also used in the making of other compounds. Amitriptynol can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Amitriptynol
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.