Alprostadil

Alprostadil structural formula

CAS Number745-65-3
Molecular FormulaC20H34O5
Molecular Weight354.487
InChI KeyGMVPRGQOIOIIMI-DWKJAMRDSA-N
LogP3.20
Synonyms
  • Alprostadil
  • (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid
  • Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)-
  • 745-65-3
  • Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11?,13E,15S)-
  • (-)-Prostaglandin E1
  • 11?,15(S)-Dihydroxy-9-oxo-13-trans-prostenoic acid
  • 11?,15?-Dihydroxy-9-oxo-13-trans-prostenoic acid
  • Alprox TD
  • Caveject
  • Caverject
  • Cyclopentaneheptanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, (-)-
  • Cyclopentaneheptanoic acid, 3?-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-
  • Eglandin
  • Lipoprost
  • Liprostin
  • l-Prostaglandin E1
  • Minprog
  • NSC 165559
  • Prostaglandin E1
  • Prostandin
  • Prostandin 500
  • Prostin VR Pediatric
  • Prostivas
  • SEPA-alprostadil
  • SEPA-prostaglandin E1
  • Topiglan
  • Vasaprostan
  • EINECS 212-017-2
  • l-3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid
  • 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid
  • (-)-Protaglandin E1
  • Alprox-TD
  • Caverject Impulse
  • Alprostadilum
  • UNII-F5TD010360
  • Promostan
  • Femprox
  • (+)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoate
  • (+)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoic acid
  • (-)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoate
  • (-)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoic acid
  • (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid
  • (13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoate
  • (13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoic acid
  • (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate
  • (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoic acid
  • (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
  • (13e)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoic acid
  • 11,15-Dihydroxy-9-oxoprost-13-en-1-oate
  • 11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid
  • 11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (ACD/Name 4.0)
  • 11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid
  • 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoate
  • 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoic acid
  • 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid
  • Alprostadil Prostoglandin E1
  • Alprostadil(usan)
  • Befar
  • EDEX
  • MUSE
  • PGE-1
  • PGE1
  • Prink
  • Prink (TN)
  • Prostin VR

Applications:

Separation of Alprostadil on Newcrom R1 HPLC column

May 16, 2018
Separation of Alprostadil on Newcrom R1 HPLC column

Alprostadil can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Alprostadil
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.