Acetic anhydride

CAS Number108-24-7
Molecular FormulaC4H6O3
Molecular Weight102.09
InChI KeyWFDIJRYMOXRFFG-UHFFFAOYSA-N
LogP-0.1
Synonyms
  • ACETIC ANHYDRIDE
  • Acetyl acetate
  • 108-24-7
  • Acetanhydride
  • Acetyl anhydride
  • Ethanoic anhydride
  • Acetic oxide
  • Acetyl oxide
  • Acetic acid, anhydride
  • Acetyl ether
  • acetic acid anhydride
  • Anhydride acetique
  • Anidride acetica
  • Octowy bezwodnik
  • Azijnzuuranhydride
  • Essigsaeureanhydrid
  • Ethanoic anhydrate
  • Anhydrid kyseliny octove
  • Ac2O
  • (CH3CO)2O
  • Acetic acid, 1,1'-anhydride
  • HSDB 233
  • UNII-2E48G1QI9Q
  • 2E48G1QI9Q
  • CHEBI:36610
  • Caswell No. 003A
  • MFCD00008705
  • Octowy bezwodnik [Polish]
  • Azijnzuuranhydride [Dutch]
  • ethanoyl ethanoate
  • Anidride acetica [Italian]
  • Anhydride acetique [French]
  • Essigsaeureanhydrid [German]
  • CCRIS 688
  • Anhydrid kyseliny octove [Czech]
  • EINECS 203-564-8
  • UN1715
  • EPA Pesticide Chemical Code 044007
  • acetanhydrid
  • BRN 0385737
  • acetic anhydrid
  • actic anhydride
  • diacetyl oxide
  • acetic-anhydride
  • acetic, anhydride
  • AcOAc
  • Acetyltrimethyl-Silane
  • acetic acetic anhydride
  • Acetic anhydride [UN1715] [Corrosive]
  • acetic acid acetyl ester
  • CAPPING REAGENT A
  • Acetyl ether Acetyl oxide
  • (MeCO)2O
  • DSSTox_CID_4395
  • SCHEMBL523
  • Acetic anhydride ACS grade
  • EC 203-564-8
  • acetic acid-acetic anhydride
  • (Ac)2O
  • Acetic anhydride, >=99%
  • Acetic anhydride, 99.5%
  • DSSTox_RID_77387
  • DSSTox_GSID_24395
  • Acetic Anhydride Reagent ACS
  • 4-02-00-00386 (Beilstein Handbook Reference)
  • MLS002454384
  • CHEMBL1305819
  • DTXSID0024395
  • HMS3039J03
  • BCP20665
  • ZINC8585917
  • Acetic anhydride, JIS special grade
  • Tox21_200278
  • STL264203
  • AKOS015915487
  • MCULE-9184217748
  • UN 1715
  • NCGC00091802-01
  • NCGC00091802-02
  • NCGC00257832-01
  • Acetic anhydride, reagent grade, >=98%
  • BP-24367
  • BP-31054
  • CAS-108-24-7
  • SMR001372001
  • Acetic anhydride [UN1715] [Corrosive]
  • Acetic anhydride, ACS reagent, >=98.0%
  • Acetic anhydride, ReagentPlus(R), >=99%
  • Acetic anhydride, p.a., ACS reagent, 97.0%
  • Acetic anhydride, SAJ first grade, >=93.0%
  • A801828
  • Acetic anhydride, Lonza quality, >=99.5% (GC)
  • Q407775
  • Acetic anhydride, for GC derivatization, >=99.0%
  • Acetic anhydride, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.0%
  • Acetic anhydride, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99% (GC)

Applications:

HPLC Method for Analysis of Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride on Newcrom R1 Column

June 3, 2022

Separation type: Liquid Chromatography Reverse Phase.


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High Performance Liquid Chromatography (HPLC) Method for Analysis of Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride

Acetic Anyhydride is a common reagent in organic synthesis, particularly in the acetylation of alcohols, amines, and aromatic rings. Benzyl Alcohol is a popular organic solvent and preservative used in topical drugs, cosmetics, and intravenous drugs. Benzoic Anhydride is the anhydride form of Benzoic Acid and a common reagent in organic synthesis. These 3 organic compounds can be separated and analyzed on a Newcrom R1 reverse-phase column using a simple gradient analytical method with a mobile phase consisting of just water and Acetonitrile (MeCN) (with no ionic modifier). This analysis method can be UV detected at 200 or 275 nm with high resolution and peak symmetry.

 

Condition
Column Newcrom R1, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 20-100%
Buffer No
Flow Rate 0.5 ml/min
Detection UV 200, 275nm

Description
Class of Compounds Acid, Hydrophilic
Analyzing Compounds Acetic Anhydride, Benzyl Alcohol and Benzoic Anhydride

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Acetic anhydride
Benzoic anhydride
Benzyl alcohol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of (2H3)Acetic anhydride on Newcrom R1 HPLC column

May 16, 2018
Separation of (2H3)Acetic anhydride on Newcrom R1 HPLC column

(2H3)Acetic anhydride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Acetic anhydride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.