Malathion

Malathion structural formula

CAS Number121-75-5
Molecular FormulaC10H19O6PS2
Molecular Weight330.351
InChI KeyJXSJBGJIGXNWCI-UHFFFAOYSA-N
LogP2.36
Synonyms
  • Malathion
  • Diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate
  • Butanedioic acid, 2-[(dimethoxyphosphinothioyl)thio]-, diethyl ester
  • 121-75-5
  • Butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester
  • [(Dimethoxyphosphinothioyl)thio]butanedioic acid diethyl ester
  • American Cyanamid 4,049
  • Butanedioic acid, 2-[(dimethoxyphosphinothioyl)thio]-, 1,4-diethyl ester
  • Carbetovur
  • Carbetox
  • Carbofos
  • Carbophos
  • Cimexan
  • Cythion
  • Derbac M
  • Diethyl mercaptosuccinate S-ester with O,O-dimethyl phosphorodithioate
  • DIETHYL MERCAPTOSUCCINATE, ESTER WITH DIMETHYLPHOSPHORODITHIOATE
  • Diethyl(dimethoxyphosphinothioylthio) succinate
  • Ethiolacar
  • Extermathion
  • Forthion
  • Fosfothion
  • Fosfotion
  • Fyfanon
  • Gammaxine
  • Hilthion
  • Hi-Yield
  • Insecticide 4049
  • Insecticide no. 4049
  • Karbofos
  • Malafor
  • Malamar
  • Malasol
  • Malaspray
  • Malataf
  • Malathine
  • Malathion E 50
  • Malathion ULV
  • Malathyl
  • Malathyne
  • malation
  • Malatol
  • Malatol 500CE
  • Maldison
  • Mavidan
  • Mercaptothion
  • Moscarda
  • NSC 6524
  • O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate
  • O,O-Dimethyl-S-(1,2-diethoxycarbonylethyl)-phosphoro dithioate
  • Oleophosphothion
  • Organoderm
  • Ortho Malathion
  • Phosphothion
  • Prioderm
  • Radotion
  • Radotion P 5
  • S-[1,2-Bis(carbethoxy)ethyl] O,O-dimethyl dithiophosphate
  • S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl phosphorodithioate
  • S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl thiophosphate
  • S-1,2-bis(Ethoxycarbonyl)ethyl O,O-dimethylphosphorodithioate
  • Sadofos
  • Sadophos
  • Security
  • Siptox I
  • Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate
  • Suleo M
  • Sumitox
  • Zithiol
  • S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate
  • S-(1,2-Bis(ethoxycarbonyl)ethyl) O,O-dimethyl phosphorodithioate
  • S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate
  • BRN 1804525
  • Camathion
  • Carbethoxy malathion
  • Chemathion
  • Compound 4049
  • Detmol MA
  • S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate
  • S-(1,2-Dicarbethoxyethyl) O,O-dimethylphosphorodithioate
  • Dicarboethoxyethyl O,O-dimethyl phosphorodithioate
  • S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate
  • Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate
  • Diethyl (dimethoxyphosphinothioylthio)succinate
  • Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester
  • Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate
  • Diethyl(dimethoxythiophosphorylthio)succinate
  • ((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester
  • O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl) dithiophosphate
  • O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate
  • Dorthion
  • EINECS 204-497-7
  • Emmatos Extra
  • Fosfotion 550
  • Kill-A-Mite
  • Kop-thion
  • Malacide
  • Malagran
  • Malakill
  • Malaphos
  • Malathiazol
  • Malathion E50
  • Malathon
  • Malatox
  • Malphos
  • Mercaptosuccinic acid diethyl ester
  • NCI-C00215
  • Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate
  • Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle)
  • Mercaptotion
  • O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat
  • O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat
  • O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan
  • S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat
  • S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat
  • S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato
  • UNII-U5N7SU872W
  • O,O-dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl)
  • O,O-dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate
  • O,O-dimethyl S-1,2-di(ethoxycarbamyl)ethyl
  • O,O-dimethyldithiophosphate diethylmercaptosuccinate
  • diethyl (dimethoxyphosphinothioylthio)succinate
  • 11096-67-6
  • 11130-60-2
  • 12737-19-8
  • 12767-62-3
  • 141263-96-9
  • 75513-83-6

Applications:

Malathion Analysis on Obelisc and Primesep Mixed-Mode HPLC Column

August 24, 2015

 

Malathion is the most widely used organophosphate pesticide used in the US. Used heavily in residential landscaping and in public recreation areas, malathion is often used for fruit fly and mosquito eradication. While not considered toxic to humans, malathion metabolizes to a far more toxic malaoxon. The EURL (European Union Reference Laboratory), included malathion as a target pesticide for the EUPT-CF9 a proficiency test for cereals and feedingstuff that require muli-residue methods. Primesep B2 and Obelisc R were used to retain malathion and separate it from impurities. Primesep B2 contains embedded basic ion-pairing groups and Obelisc R contains embedded ionic and hydrophobic groups which can assist in fine tuning separations. Method is LC/MS compatible and can be used as a general approach for analyzing malathion, other organophosphate insecticides, and dozens of other pesticides.

 

Condition 1
Column Primesep B2, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-70%, 15 min,  7 min hold
Buffer Gradient AmAc pH 4,5- 20-50 mM, 15 min,  7 min hold
Flow Rate 0.4 ml/min
Detection UV, 250 nm

 

Condition 2
Column Obelisc R, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-70%, 15 min,  7 min hold
Buffer Gradient AmAc pH 4,5- 20-50 mM, 15 min,  7 min hold
Flow Rate 0.4 ml/min
Detection UV, 250 nm

 

 

Description
Class of Compounds
  Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Malathion

 

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options

Primesep B2

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Malathion
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Analysis of Malathion

August 10, 2015

Malathion is the most widely used organophosphate pesticide used in the U.S.. Used heavily in residential landscaping and in public recreation areas, malathion is often used for fruit fly and mosquito eradication. While not considered toxic to humans, malathion metabolizes to a far more toxic malaoxon. The EURL included malathion as a target pesticide for the EUPT-CF9. Obelisc R was used to retain malathion and separate it from impurities. Obelisc R contains embedded ionic and hydrophobic groups which can assist in fine tuning separations. Method is LC/MS compatible and can be used as a general approach for analyzing malathion and other organophosphate insecticides.

Condition 2
Column Obelisc R, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN – 40%
Buffer AmFm pH 3.0- 20 mM
Flow Rate 1.0 ml/min
Detection UV, 250 nm

 

 

Description
Class of Compounds
  Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Malathion

 

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options
Application Analytes:
Malathion
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.